A 120-membered chalcone library has been designed and prepared from six differently substituted acetophenones (A1-A6) and 20 benzaldehydes (B1-B20). The library was subjected to biological studies targeted against six bacterial strains. For the identification of the most-active member(s) of the library, the so-called indexed or positional-scanning method was applied. Six out of 26 sub-libraries, i.e., AL1-AL6, were synthesized by keeping the acetophenone moiety A fixed and using equimolar quantities of the 20 different benzaldehydes. The remaining 20 sub-libraries BL1-BL20 were prepared by keeping the benzaldehyde B component fixed and varying the six acetophenones (Table 1). The bactericidal activities of the resulting sub-libraries were tested and used as indices to the rows or columns of a two-dimensional matrix. Finally, parallel synthesis of 24 specific members with the highest-expected antibacterial activities, present in two sub-libraries, was carried out. These chalcones were screened again, and the results were exploited for establishing the structure-activity relationship (SAR) and the identification of the lead compound, which turned out to be 1,3-bis(2-hydroxyphenyl)prop-2-en-1-one (A2B2) in terms of activity towards Staphylococcus aureus and Bacillus subtilis (Tables 5-7).
: Burnout is a state of physical and mental exhaustion that results from long term involvement in work situations that are emotionally demanding. Doctors in emergency fields like obstetrics & gynecology of a tertiary care hospital, have to work vigilantly at odd times under immense pressure during long duty hours, thus are more likely to burnout, especially in the tedious time of COVID-19 pandemic. This study measured the burnout in doctors of the department of OB/GYN at RMU allied hospitals by using Questionnaire based on Copenhagen Inventory with addition of questions about PPE, COVID testing facility and family burnout. Results showed inadequate provision of PPE & Covid testing, fear of transmission of infection to family and friends, effect on care of elderly at home, relationship with partner and increased mood irritability. Personal burnout was 54, work related burnout 49.6, and patient related burnout was 37 There is significant family and personal burnout but still patient burnout is not present, showing high professionalism in our doctors. Facilitation in the form of reduced working hours, safer working environment, appreciation of work, financial incentives, social support and care of psychological well-being by cognitive behavioral therapy & counselling must be offered to the doctors of the department of obstetrics and gynecology.
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