Spectrin beta, non-erythrocytic 1 cooperates with suppressor of variegation 3-9-enhancer of zeste-trithorax domain containing lysine methyltransferase 7 to promote Yesassociated protein methylation, enhancing autophagy of hepatic stem cells, hepatocellular carcinoma cells, and hepatocytes. Loss of spectrin beta, non-erythrocytic 1 promotes expansion and malignant transformation of hepatic stem cells via inhibiting autophagy during hepatocarcinogenesis.
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