Solid polymer electrolyte
(SPE) is one of the choices for many ionic devices, including organic
transistors, ion batteries, memristors, and more. However, uncontrollable
conductive filament formation seriously affects the performance of
the device. In this paper, the PEDOT:PSS was doped to improve the
electronic and ionic conductivity of amorphous polymer electrolyte
poly(vinylpyrrolidone) (PVP), realizing the transition of the filaments
growth from cathode to anode in atomic switch memristors. Based on
the difference in ion and electron mobility and scanning electron
microscope observation, the in situ reductions of metal ions inside
the dielectric layer can effectively prevent the formation of uncontrollable
filaments. The formation of uniformly distributed metal particles
in the dielectric layer is similar to co-sputter doping technology,
which enables the device to exhibit excellent performance, such as
smaller set/reset bias distribution, endurance, and retention. Obviously,
this innovative way improves the conductive mechanism of ionic devices.
Organic polymer solid electrolytes show interesting application prospects in resistive switching memories and brain-inspired computing ionic devices. However, polymer electrolytes can easily decompose under heat treatment and their ionic conductivity can vary significantly at different temperatures. Among the reported polymer memristors, most of them lack sufficient reproducibility, endurance, stability, uniformity, and inter alia heat tolerance. Based on a molecular group that is thermally stable over a large temperature range and a structure with polar bonds for assisted ion migration, herein, a new polymer memristor is demonstrated employing polyethyleneimine (PEI) as a solid electrolyte for the first time. Atomic switch memristors equipped with PEI solid polymer electrolyte exhibit stable resistive switching at room temperature and high temperatures with a good retention, large ON/OFF ratio of 10 5 , and stable cycle performance within a temperature range from 25 to 150 °C. The memristors fabricated on a polyimide substrate exhibit excellent switching performance at 150 °C after 2000 bending cycles, illustrating the potential for flexible electronic applications. Structural analysis reveals that the excellent thermally stable switching performance is derived from the stability of the molecular chain and a lower T g (glass transition temperature).
Flowering time control is critically important for the reproductive accomplishment of higher plants as floral transition can be affected by both environmental and endogenous signals. Flowering Locus T-like (FTL) genes are major genetic determinants of flowering in plants. In rice, 13 OsFTL genes have been annotated in the genome and amongst them, Hd3a (OsFTL2) and RFT1 (OsFTL3) have been studied extensively and their functions are confirmed as central florigens that control rice flowering under short day and long day environment, respectively. In this report, a rice OsFTL gene, OsFTL10, was characterized, and its function on flowering and abiotic stress was investigated. The expression level of OsFTL10 was high in young seedlings and shown to be induced by GA3 and drought stress. Overexpression of OsFTL10 resulted in earlier flowering in rice plants by up to 2 weeks, through up-regulation of the downstream gene OsMADS15. OsFTL10 also regulated Ehd1 and OsMADS51 through a feedback mechanism. The OsFTL10 protein was also detected in both nucleus and cytoplasm. Furthermore, yeast two hybrid (Y2H) and bimolecular fluorescence complementation (BiFC) results show that OsFTL10 could interact with multiple 14-3-3s, suggesting that OsFTL10 might function in a similar way to Hd3a in promoting rice flowering by forming a FAC complex with 14-3-3, and OsFD1. Further experiments revealed that constitutive expression of OsFTL10 improved the drought tolerance of transgenic plants by stimulating the expression of drought responsive genes. These results suggest that rice FTL genes might function in flowering promotion and responses to environmental signals.
grade >3. The latter were represented by infections (n = 7), neutropenia (n = 7), arrhythmias (n = 4), arterial hypertension (n = 7), myalgias (n = 3). Two cases of sudden death were reported. Response of AIHA was evident in all patients. By day 141 4 (21%) patients achieved a DATve CR, 10 (53%) DAT+ve CR, 1 -DAT-ve PR and 4 (21%) DAT+ve PR. All PR patients achieved transfusion independence. Two patients with PRCA achieved a CR by days 84 and 150, and 1 patient did not respond. Response of CLL, assessed at day 225 by IWCLL 2008 criteria was available in 19 patients. Seven patients (37%) achieved a CR, including one MRD-negative case. Twelve patients (63%) were classified as PRs because of residual bone marrow infiltration (n = 12) along with persistent splenomegaly (n = 3) or persistent neutropenia (n = 2). No patients have relapsed so far. Summary/Conclusion: The combination of ibrutinib and rituximab demonstrated high activity in the treatment of patients with relapsed and steroid refractory AIHA with underlying CLL. The safety profile of IR combination corresponded to published data.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.