Leading institutions throughout the country have established Precision Medicine programs to support personalized treatment of patients. A cornerstone for these programs is the establishment of enterprise-wide Clinical Data Warehouses. Working shoulder-to-shoulder, a team of physicians, systems biologists, engineers, and scientists at Rutgers Cancer Institute of New Jersey have designed, developed, and implemented the Warehouse with information originating from data sources, including Electronic Medical Records, Clinical Trial Management Systems, Tumor Registries, Biospecimen Repositories, Radiology and Pathology archives, and Next Generation Sequencing services. Innovative solutions were implemented to detect and extract unstructured clinical information that was embedded in paper/text documents, including synoptic pathology reports. Supporting important precision medicine use cases, the growing Warehouse enables physicians to systematically mine and review the molecular, genomic, image-based, and correlated clinical information of patient tumors individually or as part of large cohorts to identify changes and patterns that may influence treatment decisions and potential outcomes.
In
practical applications, the mechanical properties of halide
perovskites (e.g., ABX3; A = monovalent
cation; B = divalent metal cation; X = halogen anion) are of fundamental
importance in achieving the durability of perovskite-based devices.
In contrast to the widely studied photovoltaic properties, the composition/structure–mechanical
property relationship in halide perovskites remains largely unexplored.
Here, taking cesium-based halide perovskite models as examples, we
have investigated the effects of chemical composition, phase transition,
structural dimensionality, octahedral layer thickness, and octahedral
connectivity on their mechanical properties using first-principles
calculations. Our calculations show that the geometric factors (i.e., ionic radius, bond length, and tolerance factor) can
reasonably explain the elastic property trends when varying the X-site
component. The electronic factors (i.e., electronegativity)
also play an important role in determining the mechanical strength
when varying the B-site component. The phase transition, the structural
dimensionality, the thickness of the [BX6] octahedral layer,
and the [BX6] octahedral connectivity have a crucial influence
on the mechanical properties if the chemical composition remains unchanged.
Our results provide valuable insights into the composition/structure–mechanical
property relationship of halide perovskites, which can guide the material
design and device optimization to achieve desired mechanical properties.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.