5Fluorescent organic nanoparticles (FNPs) have attracted great research interest for biological sensor, biological imaging and disease treatment. However, preparation of ultrabright FNPs using conventional organic dyes is still challenge for their aggregation caused quenching effect. In this work, we reported for the first time that polyethylene glycol (PEG) and an aggregation induced emission (AIE) dye 2,2'diaminotetraphenyl ethylene (DATPE) can be facilely conjugated by trimellitic anhydride chloride. Taken 10 advantage of the different reaction activity of anhydride and choloride, anhydride-terminated PEG (ADPEG) was first synthesized through the reaction between hydroxyl groups and benzoyl choloride. And then ADPEG could further react with the amino groups of DATPE. Because of the AIE property of DATPE, these amphiphilic triblock copolymers can self assemble into FNPs (PEG-TPE FNPs) and emit strong blue-green fluorescence in aqueous solution. Cell uptake behavior and cytotoxicity evaluation 15 suggested that PEG-TPE FNPs possessed excellent cytocompatibility and could be facilely uptaken by cells, implying that PEG-TPE FNPs are promising for biomedical applications. More importantly, this method described in this work is rather simple, effective and more importantly can be extended to fabricate many other multifunctional FNPs at large scale for various biomedical applications. 75 Electronic Supplementary Information (ESI) available: [ 1 H NMR of DATPE, photostability of PEG-TPE FNPs, hydrodyanmic size of PEG-15 TPE FNPs and AIE property of DATPE.]. See
The urban heat island (UHI) effect refers to the phenomenon in which urban temperature is generally higher than that of rural surroundings. The UHI can have a significant impact on human health (
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