The direct transformation of aryl carboxylic acids to
aryl nitrile
compounds is an interesting topic because carboxylic acids are not
only abundant in nature but are also inexpensive and stable. Here,
the synthesis of a series of aryl nitriles by palladium-catalyzed
decarbonylative cyanation of carboxylic acids without base has been
achieved. The successful decarbonylative cyanation of drug molecules
and Gram-scale reaction to verify the practicality and operability
of this method are analyzed.
An example of activation of the -SO2F group, which is traditionally considered a stable group even in the presence of a transition metal, is described, using a novel partner in...
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