Purpose: The aim of the study was to explore a fast PET scan protocol of the total-body uEXPLORER scanner by assessing the image quality consistent to that of a conventional digital PET/CT scanner both from the phantom and clinical perspectives.Methods: The phantom study using a NEMA/IEC NU-2 body phantom was performed both on a totalbody PET/CT (uEXPLORER) and a digital routine PET/CT (uMI 780), with hot sphere to background activity concentration ratio of 4:1. The contrast recovery coe cient (CRC), background variability (BV), recovery coe cient RCmax and RCmean were assessed and compared between that in uEXPLORER with the different scanning duration and reconstruction protocols and that in uMI 780 with clinical settings.The coe cient of variation (COV) of the uMI 780 with clinical settings were calculated and used as a threshold to determine the optimized scanning duration and reconstruction protocols were, which can provide a consistent image quality for the two scanners. And subsequently, the proposed protocol was validated by 30 oncological patients. Images acquired in uMI 780 with a 2-3 minute for each bed position were referred as G780. All PET raw data were reconstructed using data-cutting technique to simulate a 30s, 45s or 60s acquisition duration on uEXPLORER. The iterations were 2 and 3 for uEXPLORER, referred as G30s_3i, G45s_2i, G45s_3i, G60s_2i, and G60s_3i. A 5-point Likert scale was used in the qualitative analysis to assess the image quality. The image quality was also compared with the liver COV, the lesion target-to-background ratio (TBR), and the lesion signal-to-noise ratio (SNR).Results: In the phantom study, CRC, BV, RCmax and RCmean in uEXPLORER with different scanning duration and reconstruction iterations were compared with that in uMI 780 with clinical settings and a minor uctuation was found among different scanning durations. COV of the uMI 780 with clinical settings was 11.6% and determined protocol with a 30-45s scanning duration and 2 or 3 iterations to provide a similar image quality.In the quantitative analysis on the clinical images, there was no signi cant difference between G780 and G45s_3i. All the other groups in uEXPLORER with a 45s-and above acquisition showed a signi cantly improved image quality than that in uMI 780 with clinical settings. Comparing the liver COV, there was no signi cantly difference between G780 and G30s_3i. And no signi cant difference in lesion TBR was identi ed between G780 and G45s_2i, while uEXPLORER had a better performance in lesion SNR compared to that in uMI 780 with clinical settings.Conclusions: This study demonstrated a fast PET protocol with a 30-45s acquisition in uEXPLORER with consistent image quality to that in uMI 780 with clinical settings.
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