No abstract

Various robotic exoskeletons have been proposed for hand function assistance during activities of daily living (ADL) of stroke survivors. However, traditional exoskeletons involve the use of complex rigid systems that impede the natural movement of joints, and thus reduce the wearability and cause discomfort to the user. The objective of this paper is to design and evaluate a soft robotic glove that is able to provide hand function assistance using fabric-reinforced soft pneumatic actuators. These actuators are made of silicone rubber which has an elastic modulus similar to human tissues. Thus, they are intrinsically soft and compliant. Upon air pressurization, they are able to support finger range of motion (ROM) and generate the desired actuation of the finger joints. In this work, the soft actuators were characterized in terms of their blocked tip force, normal and frictional grip force outputs. Combining the soft actuators and flexible textile materials, a soft robotic glove was developed for grasping assistance during ADL for stroke survivors. The glove was evaluated on five healthy participants for its assisted ROM and grip strength. Pilot test was performed in two stroke survivors to evaluate the efficacy of the glove in assisting functional grasping activities. Our results demonstrated that the actuators designed in this study could generate desired force output at a low air pressure. The glove had a high kinematic transparency and did not affect the active ROM of the finger joints when it was being worn by the participants. With the assistance of the glove, the participants were able to perform grasping actions with sufficient assisted ROM and grip strength, without any voluntary effort. Additionally, pilot test on stroke survivors demonstrated that the patient's grasping performance improved with the presence and assistance of the glove. Patient feedback questionnaires also showed high level of patient satisfaction and comfort. In conclusion, this paper has demonstrated the possibility of using soft wearable exoskeletons that are more wearable, lightweight, and suitable to be used on a daily basis for hand function assistance of stroke survivors during activities of daily living.

No abstract

Interethnic difference in VKORC1 haplotypes accounts for the difference in warfarin requirements between Chinese, Malays, and Indians, providing interesting insights into genetic variation between ethnogeographically distinct Asian groups.

Despite the emergence of flexible and stretchable actuators, few possess sensing capabilities. Here, we present a facile method of integrating a flexible pneumatic actuator with stretchable strain sensor to form a soft sensorized actuator. The elastomeric actuator comprises a microchannel connected to a controlled air source to achieve bending. The strain sensor comprises a thin layer of screen‐printed silver nanoparticles on an elastomeric substrate to achieve its stretchability and flexibility while maintaining excellent conductivity at ≈8 Ω sq–1. By printing a mesh network of conductive structures, our strain sensor is able to detect deformations beyond 20% with a high gauge factor beyond 50 000. The integration of a pneumatic soft actuator with our sensing element enables the measurement of the extent of actuator bending. To demonstrate its potential as a rehabilitation sensing actuator, we fit the sensorized actuator in a glove to further analyze finger kinematics. With this, we are able to detect irregular movement patterns in real time and assess finger stiffness or dexterity.

Coronavirus disease 2019 (COVID-19) has rapidly spread not only in China but throughout the world. Children with kidney failure (chronic kidney disease (CKD) stage 5) are at significant risk for COVID-19. In turn, a set of recommendations for the prevention and control of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 in pediatric hemodialysis (HD) centers and in home peritoneal dialysis (PD) settings have been proposed. The recommendations are based on the epidemiological features of the SARS-CoV-2 virus and COVID-19 disease, susceptibility factors, and preventive and control strategies. These recommendations will be updated as new information regarding SARS-CoV-2 and COVID-19 becomes available.

Polymorphisms in CBR3 may explain interindividual and interethnic variability of doxorubicin pharmacokinetics and pharmacodynamics.

This paper presents a soft robotic glove designed to assist individuals with functional grasp pathologies in performing activities of daily living. The glove utilizes soft fabric-regulated pneumatic actuators that are low-profile and require lower pressure than previously developed actuators. They are able to support fingers and thumb motions during hand closure. Upon pressurization, the actuators are able to generate sufficient force to assist in hand closing and grasping during different manipulation tasks. In this work, experiments were conducted to evaluate the performances of the actuators as well as the glove in terms of its kinetic and kinematic assistance on a healthy participant. Additionally, surface electromyography and radio-frequency identification techniques were adopted to detect user intent to activate or deactivate the glove. Lastly, we present preliminary results of a healthy participant performing different manipulation tasks with the soft robotic glove controlled by surface electromyography and radio-frequency identification techniques.