Ultrathin metal-organic framework (MOF) nanosheets (NSs) offer potential for many applications,b ut the synthetic strategies are largely limited to top-down, low-yield exfoliation methods.H erein, Ni-M-MOF (M = Fe,A l, Co, Mn, Zn, and Cd) NSs are reported with at hickness of only several atomic layers,p repared by al arge-scale,b ottom-up solvothermal method. The solvent mixture of N,N-dimethylacetamide and water playskey role in controlling the formation of these two-dimensional MOF NSs.T he MOF NSs can be directly used as efficient electrocatalysts for the oxygen evolution reaction, in which the Ni-Fe-MOF NSs deliver ac urrent density of 10 mA cm À2 at al ow overpotential of 221 mV with asmall Tafel slope of 56.0 mV dec À1 ,and exhibit excellent stability for at least 20 hw ithout obvious activity decay. Density functional theory calculations on the energy barriers for OER occurring at different metal sites confirm that Fe is the active site for OER at Ni-Fe-MOF NSs.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

In the first trimester, the reference range of IT in Chinese fetuses has been established. The assessment of IT is feasible and reproducible.

In the first trimester, the FMF angle decreases with fetal CRL. There was similarity in the normal value of FMF angle between the Chinese and Caucasian populations.

Glycation of blood proteins is considered to be a major contributor to hyperglycemic complications in diabetes mellitus patients. In this study, we demonstrate the efficacy of alpha-tocopherol in reducing low-density lipoprotein (LDL) oxidation and glycation in vitro. Native LDL isolated from healthy subjects was exposed to various concentrations of glucose and malondialdehyde (MDA) with or without alpha-tocopherol enrichment for 7 days in sealed vacuum ampoules. The degree of glycation, copper-induced lag time, content of thiobarbituric acid-reactive substances (TBARS), and alpha-tocopherol levels in LDL were then assessed. LDL lag time was significantly reduced with high levels of glucose and MDA. Alpha-tocopherol enrichment dramatically inhibited the oxidation of LDL in the lag-time assay. However, the length of incubation time was inversely related to the LDL lag time. Longer incubation time resulted in shorter LDL lag time, with or without alpha-tocopherol enrichment. The level of TBARS associated with LDL oxidation was highest in native, MDA-supplemented, and high-glucose samples. The alpha-tocopherol levels were inversely related to glucose levels and incubation times. In conclusion, high-glucose concentrations heightened the oxidative susceptibility of LDL. Alpha-tocopherol enrichment reduced this trend and prevented LDL from undergoing architectural modification.

There was significant intermethod difference between the results obtained by 2D and 3D, as well as substantial interobserver variation in 3D measurement of fetal nasal bone length in the first trimester. Independent 3D measurement of nasal bone offers no additional advantages over 2D sonography.