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There is no consensus about the role of adjunctive hyperbaric oxygen therapy (HBOT) in the management of Fournier’s gangrene. The aim of this study was to compare the evolution of patients with Fournier’s gangrene treated with all classical measures with and without adjuvant HBOT. A retrospective comparative study regarding the evolution of patients treated for Fournier’s gangrene was conducted in two periods. In period I, from 1990 to 2002, patients received standard treatments for Fournier’s gangrene, which consisted of surgical debridement, antibiotic therapy and intensive care. In period II, from 2012 to 2019, adjunctive HBOT was added to the classical management strategy. All patients were assigned into four groups according to the anatomical severity classification and the area affected after the first debridement. This classification ensured that the groups could be comparable. The total number of patients in this study was 197, and these patients were divided into control group (118/59.9%) and HBOT group (79/40.1%). The mean age, comorbidities, and anatomical severity classification were similar between the two groups. In period I, 34 out of 118 (28.8%) patients died, while in the HBOT group, 3 out of 77 (3.7%) patients died ( P < 0.001). The use of adjuvant HBOT in combination with classical treatment was associated with reduced mortality. This study was approved by the Institutional Review Board and the Ethics Committee of Ribeirão Preto Medical School, University of São Paulo, Brazil (No. 08/2018) on May 2, 2018.

Purpose To evaluate the gene expression of peroxisome proliferator activated receptors gamma (PPARG) in colorectal tumors and to correlate this data with clinical variables of the patients. Methods We analyzed the gene expression of PPARG in 50 samples of colorectal tumors using real-time reverse transcription polymerase chain reaction, and 20 adjacent normal tissue samples as control. The results of these quantifications were correlated with the respective patients’ medical records’ clinical information. Results PPARG expression was not different in the tumor tissue compared to the control tissue. Patients older than 60 years, histological type with mucinous differentiation, more advanced staging at the time of diagnosis, and patients who evolved with recurrence of the disease or death did not present higher PPARG expression. Conclusion Expression of PPARGD was not associated with worse prognosis.

Objective The purpose was to assess the rates of postoperative complications and the need of temporary stoma of laparoscopic surgical treatment for bowel endometriosis in a referral center. Methods The surgical indication, type of operation, operative time, length of hospital stay, need for a temporary stoma, rate of conversion to open surgery, postoperative complications were evaluated. Results One-hundred and fifty patients were included. The average duration of surgery was significantly longer for segmental resection (151 minutes) than for disc excision (111.5 minutes, p < 0.001) and shaving (96.8 minutes, p < 0.001). Patients with segmental resection had longer postoperative lengths of hospital stay (1.87 days) compared with patients with disc excision (1.43 days, p < 0.001) and shaving (1.03 days, p < 0.001). A temporary stoma was performed in 2.7% of patients. Grade II and III postoperative complications occurred in 6.7% and 4.7% patients, respectively. Conclusion Laparoscopic intestinal resection has an acceptable postoperative complication rate and a low need for a temporary stoma.

RESUMO A prática de judô integra situações variadas de contato físico e exigências específicas, tornando-o uma modalidade competitiva e com alto índice de lesões musculoesqueléticas (LME). Este estudo transversal teve por objetivo descrever a epidemiologia de LME e analisar a relação entre diferentes características e a ocorrência de lesão em judocas. A casuística integrou 111 participantes de ambos os sexos. Para tomar informações sobre lesões, utilizou-se um inquérito de morbidade referida. Para análise estatística, foi empregado o teste de Goodman de proporções multinomiais. A relação entre fatores associados com LME foi avaliada por meio de regressão logística. Foram relatados 135 LME, com prevalência de 65% (72 esportistas), totalizando 1,22 LME/atleta. A maioria dos relatos foi constituída por lesões articulares decorrentes de traumas (n=50 casos, 37%), sendo que entorse de tornozelo (25,2%) e luxação de ombro (17,8%) foram os casos com maior frequência. Entre as lesões ósseas, verificou-se maior proporção de casos graves (25 casos; 18,5%). Sexo e carga horária semanal constituíram-se como as principais características preditivas para ocorrência de LME no judô (p<0,001). Conclui-se que as lesões articulares traumáticas em tornozelo e ombro foram as principais LME no judô. Sexo masculino e maior carga horária semanal constituíram-se como as principais características preditivas de lesão entre judocas.