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Habitat destruction and overexploitation are the main threats to biodiversity and where they co‐occur, their combined impact is often larger than their individual one. Yet, detailed knowledge of the spatial footprints of these threats is lacking, including where they overlap and how they change over time. These knowledge gaps are real barriers for effective conservation planning. Here, we develop a novel approach to reconstruct the individual and combined footprints of both threats over time. We combine satellite‐based land‐cover change maps, habitat suitability models and hunting pressure models to demonstrate our approach for the community of larger mammals (48 species > 1 kg) across the 1.1 million km2 Gran Chaco region, a global deforestation hotspot covering parts of Argentina, Bolivia and Paraguay. This provides three key insights. First, we find that the footprints of habitat destruction and hunting pressure expanded considerably between 1985 and 2015, across ~40% of the entire Chaco – twice the area affected by deforestation. Second, both threats increasingly acted together within the ranges of larger mammals in the Chaco (17% increase on average, ± 20% SD, cumulative increase of co‐occurring threats across 465 000 km2), suggesting large synergistic effects. Conversely, core areas of high‐quality habitats declined on average by 38%. Third, we identified remaining priority areas for conservation in the northern and central Chaco, many of which are outside the protected area network. We also identify hotspots of high threat impacts in central Paraguay and northern Argentina, providing a spatial template for threat‐specific conservation action. Overall, our findings suggest increasing synergistic effects between habitat destruction and hunting pressure in the Chaco, a situation likely common in many tropical deforestation frontiers. Our work highlights how threats can be traced in space and time to understand their individual and combined impact, even in situations where data are sparse.

Summary. Background: The ability of computed tomography (CT)-assessed right ventricular dysfunction (RVD) to identify normotensive patients with acute pulmonary embolism (PE) at high risk of mortality or adverse outcome lacks clarity. Methods and Results: We performed a systematic review and a meta-analysis of studies in normotensive patients with acute PE to assess the prognostic value of CT-assessed RVD for death and a predefined composite outcome of PE-related complications. We conducted unrestricted searches of MEDLINE and EMBASE from 1980 to March 2013, and used the terms 'computed tomography', 'pulmonary embolism', and 'prognos*'. We used a random-effects model to pool study results, funnel-plot inspection to evaluate for publication bias, and I 2 testing to assess for heterogeneity. The analysis included data from 10 studies (2288 patients). Overall, 99 of 1268 patients with RVD assessed by CT died (7.8%; 95% confidence interval [CI] 6.3-9.3) as compared with 52 of 1020 without RVD (5.1%; 95% CI 3.7-6.4). CT-assessed RVD had significant associations with mortality (odds ratio [OR] 1.8; 95% CI 1.3-2.6), with death resulting from PE (OR 7.4; 95% CI 1.4-39.5), and with PE-related complications (OR 2.4; 95% CI 1.2-4.7). Pooled likelihood ratios (LRs) were not extreme (negative LR 0.71; 95% CI 0.57-0.89; and positive LR 1.27; 95% CI 1.12-1.43). Conclusions: Although RVD assessed by CT showed an association with an increased risk of mortality in patients with hemodynamically stable PE, it resulted in only small increases in the ability to classify risk.

Vinaceous Amazons (Amazona vinacea) are endemic to the Atlantic forest of southeastern Brazil, eastern Paraguay, and the province of Misiones in Argentina. We searched for Vinaceous Amazons throughout the western part of its range in Argentina and Paraguay during 1639 days of fieldwork from 1997 to 2006. These parrots have disappeared from most areas where they were historically recorded in these countries, and are now limited to a few sites in northeastern Paraguay and central Misiones (Argentina). We estimate the minimum remaining populations at 220 individuals in Paraguay and 203 individuals in Argentina. Important sites for the species are (1) the farming area from San Pedro to Tobuna (Misiones, Argentina) and (2) the Itaipú reserves complex and Reserva Natural Privada Itabó (Paraguay). In our surveys, Vinaceous Amazons were absent from the largest tracts of forest in Misiones, and were most often observed feeding, roosting, and nesting in small forest remnants and in agricultural areas that included forest fragments and isolated trees. Threats to amazons in these areas include nest poaching, forest clearing, and being shot as a crop pest. We confirmed 40 Vinaceous Amazons kept as pets in 35 homes between San Pedro and Tobuna. Environmental education and law enforcement are urgently needed to reduce threats in populated areas, and subsistence farmers need technical and logistical support to slow or stop the conversion of forest into cropland. Finally, additional study is needed to determine this amazon's habitat preferences, nest site requirements, and demography in different habitats. SINOPSIS. Distribución, abundancia y conservación del loro vinoso (Amazona vinacea) en Argentina y ParaguayEl loro vinoso (Amazona vinacea) es endémico del bosque Atlántico del sudeste de Brasil, este de Paraguay, y la provincia de Misiones en Argentina. Buscamos esta especie durante 1639 días de trabajo de campo de 1997 a 2006, a lo largo de la porción oeste de su distribución, en Argentina y Paraguay. A. vinacea ha desaparecido de la mayor parte de lasáreas donde ha sido registrada históricamente en estos paises, y permanece sólo en algunos pocos sitios del noroeste de Paraguay y del centro de Misiones (Argentina). Estimamos el tamaño mínimo de las poblaciones remanentes en 220 individuos en Paraguay y 203 individuos en Argentina. Los sitios importantes para la especie son: (1) la zona rural de San Pedro a Tobuna (Misiones, Argentina) y (2) el complejo de reservas de Itaipú y la Reserva Natural Privada Itabó (Paraguay). A. vinacea no fue encontrada en los tractos más grandes de bosque durante nuestras prospecciones en Misiones. Mayormente fue observada alimentándose, durmiendo y nidificando en pequeños remanentes boscosos y en hábitats antropogénicos. Las amenazas en estos hábitats incluyen robo de pichones de los nidos, deforestación, y cacería por daño a cultivos. Confirmamos la existencia de 40 ejemplares cautivos como mascotas en 35 hogares de San Pedro y Tobuna. Para reducir las amenazas se requieren urgentemente educaci...

ObjectivesTo evaluate the interobserver reliability of echocardiographic findings of right ventricle (RV) dysfunction for prognosticating normotensive patients with pulmonary embolism (PE).MethodsA central panel of cardiologists evaluated echocardiographic studies of 75 patients included in the PROTECT study for the following signs: RV diameter, RV/left ventricular (LV) diameter ratio, hypokinesis of the RV free wall, and tricuspid plane systolic excursion (TAPSE). Investigators used intraclass correlation to assess agreement between the measurements of the central panel and each of the local cardiologists. Investigators used the single weighted kappa statistic to test for agreement between readers of interpretation of RV enlargement and RV hypokinesis.ResultsThe two observers had fair agreement (k = 0.45) for RV enlargement assessed by the RV diameter, and good agreement (k = 0.65) for RV enlargement assessed by the RV/LV diameter ratio. The interobserver reliability of the assessment whether hypokinesis of the RV free wall is present was good (к = 0.70), and whether RV dysfunction (assessed by TAPSE measurement) is present was very good (k = 0.86). The intraclass correlation for the RV/LV diameter ratio was fair (0.55; 95% confidence interval [CI], 0.37-0.69), for the RV diameter was good (0.70; 95% CI, 0.56-0.80), and for the TAPSE measurement was very good (0.85; 95% CI, 0.77-0.90). On Bland-Altman analysis, the mean differences for RV diameter, RV/LV diameter ratio and TAPSE measurement were 2.33 (±5.38), 0.06 (±0.23) and 0.08 (±2.20), respectively.ConclusionTAPSE measurement is the least user dependent and most reproducible echocardiographic finding of RV dysfunction in normotensive patients with PE.

SummaryWe provide new information on all birds known from San Rafael National Park, Paraguay. Ornithological records from the period 1997 to 2006 have been reviewed, adding 112 new species to the reserve's avifauna. We provide data on the presence of 405 species in seven basic habitats types, and on their relative abundance. Biogeographically, San Rafael has a mixed avifauna, consisting of 70 Atlantic Forest endemic species, two Mesopotamian Grassland endemics, and many with a wider distribution in South America. At least 12 species are threatened and 16 nearthreatened, including important populations of Dryocopus galeatus, Platyrinchus leucoryphus, Alectrurus tricolor and Xanthopsar flavus. We provide brief comments on records of these 28 species within the study site. The avifauna of the reserve is one the most important in Paraguay, due to its high diversity and endemism. At the same time, it is under great threat and its viability is at risk unless urgent actions are taken. Fragmentation of the Atlantic Forest in Paraguay has left the San Rafael block almost totally isolated from other forests. The degradation of its forests through selective logging and clearance for agriculture still has severe impacts, as do hunting and frequent fires in grasslands and forests. Unfortunately, the legal situation of the National Park is extremely precarious, creating great uncertainty and problems for its conservation. ResumenAqui relatamos nuevas informaciones sobre todas las aves conocidas hasta el presente dentro del Parque Nacional San Rafael. Se han revisado registros ornitoló gicos comprendidos entre los añ os 1997 y 2006, que han permitido añ adir 112 especies nuevas para la reserva. De esta manera, San Rafael tiene un total de 405 especies registradas. Para cada una de ellas se facilitan datos que documentan su presencia en siete tipos de hábitats básicos diferenciados, y de su abundancia relativa. Biogeográficamente, la avifauna de San Rafael es una mezcla que está compuesta por 70 especies endémicas del Bosque Atlántico, dos endémicas de los Pastizales de la Mesopotamia, y el resto, son de distribución más amplia en Sudamérica. Al menos, 12 especies están amenazadas y 16 casi-amenazadas, incluyendo poblaciones importantes de Dryocopus galeatus, Platyrinchus leucoryphus, Alectrurus tricolor y Xanthopsar flavus. De éstas 28 especies, se proporcionan comentarios breves sobre sus registros en el área de estudio. La avifauna de la reserva resulta una de las más importantes dentro del Paraguay, tanto por su mayor diversidad y presencia de endemismos, como por ser una de las áreas con alto potencial para mantener la biodiversidad, al tiempo que se encuentra sometida a fuertes amenazas que ponen en peligro su viabilidad en caso de no tomarse medidas urgentes. La alta fragmentació n del Bosque Atlántico dentro del

The forest classification of Chile defines a forest type named Coigüe-Raulí-Tepa, assuming that those three species are the most characteristic of the type. To corroborate this assumption and to verify variations that occur within the andean range of the forest type, three areas through it, at 38°, 39° 30' and 40° S latitude were selected. Within these areas, 3 plots in undisturbed forest were selected for each combination of altitude -aspect. Two altitudes (600-800 and 800-1000 m.o.s.l.) and four aspects (N, S, E, and W) were considered. In each plot a general soil analysis and vegetation analysis were performed. Vegetation was stratified according to three canopy, sapligs, tree regeneration and understorey.

The STI of HAART in cycles of 4 weeks off/12 weeks on therapy in children with chronically undetectable VL can cause progressively lower viral rebounds followed by a decrease to undetectable levels, with a low risk of severe immunosuppression and without the occurrence of symptoms related to HIV.