To cite this article: Ali HO, Arroyo AB, Gonz alez-Conejero R, Stavik B, Iversen N, Sandset PM, Mart ınez C, Skretting G. The role of microRNA27a/b and microRNA-494 in estrogen-mediated downregulation of tissue factor pathway inhibitor a. J Thromb Haemost 2016; 14: 1226-37.
Essentials• Estrogens are known to influence the expression of microRNAs in breast cancer cells.• We looked at microRNAs in estrogenic regulation of tissue factor pathway inhibitor a (TFPIa).• Estrogen upregulated microRNA-27a/b and micro-RNA-494 through the estrogen receptor a.• MicroRNA-27a/b and microRNA-494 are partly involved in estrogenic downregulation of TFPIa.Summary. Background: Tissue factor pathway inhibitor (TFPI) has been linked to breast cancer pathogenesis. We have recently reported TFPI mRNA levels to be downregulated by estrogens in a breast cancer cell line (MCF7) through the estrogen receptor a (ERa). Accumulating evidence also indicates that activation of ERa signaling by estrogens may modulate the expression of target genes indirectly through microRNAs (miRNAs) .
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