IntroductIon
Purine and pyrimidine nucleotides are potent extracellular signaling molecules, are released by most tissues, and exert their effects by interacting with two classes of membrane receptors, p2X and p2y. p2y receptors are members of the large metabotropic G-protein-coupled receptor (Gpcr) family and are involved in numerous biochemical processes, including platelet function and chloride ion flux. p2y1, p2y11, p2y12, and p2y13 are activated by adenine nucleotides such as adp and atp; in contrast, p2y4 and p2y6 are activated by uridine nucleotides, and p2y2 is activated by both utp and atp.
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