Background: The aim of this study was to evaluate whether there is a superior clinical effect of unilateral biportal endoscopy compared with microscopic decompression in the treatment of lumbar spinal stenosis. Methods: We searched CNKI, WANFANG, CQVIP, CBM, PubMed, and Web of Science up to January 2022, and selected studies that met our inclusion criteria. Results: The results of this meta-analysis indicated that unilateral biportal endoscopy was demonstrated to be more beneficial for patients compared with microscopic decompression for the following outcomes: Operation time [standardized mean difference (SMD) = −0.943, 95% confidence interval (CI) (−1.856, −0.031), P = .043], hospital stays [SMD = −2.652, 95% CI (−4.390, −0.914), P = .003], EuroQol 5-Dimension questionnaire [SMD = 0.354, 95% CI (0.070, 0.638), P = .014], back pain visual analogue score [SMD = −0.506, 95% CI (−0.861, −0.151), P = .005], leg pain visual analogue score [SMD = −0.241, 95% CI (−0.371, −.0112), P = .000], the C-reactive protein level [SMD = −1.492,95% CI (−2.432, −0.552), P = .002]. Other outcomes demonstrated no significant differences between the 2 groups. Conclusion: For patients with lumbar spinal stenosis, unilateral biportal endoscopy was found to be more superior than microscopic decompression in terms of operation time, hospital stays, EuroQol 5-Dimension questionnaire, back visual analogue score, leg visual analogue score and the C-reactive protein level. There was no significant difference between the 2 groups in other outcome indicators.
Background: Several studies have shown that HEIH is overexpressed in a variety of cancers and plays a role as an oncogene in cancer. The present meta-analysis aims to elucidate the relationship between HEIH expression and prognosis and clinicopathological features among cancer patients.Materials and methods: PubMed, Web of Science, Cochrane Library, and EMBASE database were comprehensively and systematically searched. pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence interval (CI) were employed to assess the relationship between HEIH expression and clinical outcomes and clinicopathological features in cancer patients.Results: The present study finally enrolled 11 studies which included 1227 cancer patients. The combined results indicated that HEIH overexpression was significantly associated with shorter overall survival (OS) (pooled HR=2.03, 95% CI 1.74–2.38, P < 0.00001).Meanwhile, regarding clinicopathology of cancer patients, upregulated HEIH expression was closely related to larger tumor size (OR = 2.65, 95% CI: 1.52–4.65, P = 0.0006), advanced tumor T stage (OR = 2.41, 95 % CI: 1.54–3.77, P = 0.0001), advanced TNM stage (OR = 4.76, 95% CI: 2.73–8.29, P < 0.00001), distant metastasis (OR = 2.94, 95% CI: 1.75–4.96, P < 0.0001) and lymph node metastasis (OR = 2.07, 95% CI: 1.05–4.07, P = 0.04), respectively.Conclusions: High expression of HEIH in some cancers predicts shorter overall survival and higher clinical stage as well as larger tumor size. HEIH has great potential to become a prognostic marker for cancer patients.
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