Enterovirus 71 (EV71) is the principal pathogen leading to severe cases of hand, foot, and mouth disease (HFMD). Specific drugs for EV71 are not discovered currently. Small interfering RNA (siRNA) provides a promising antiviral treatment pathway, but it is difficult to cross cell membranes and is easy to degrade. Nanoparticles are promising for their carrying capacity currently. In this study, the siRNA targeting EV71 VP1 gene was loaded with selenium nanoparticles (SeNPs) and surface decorated with polyethylenimine (PEI) (Se@ PEI@siRNA). Se@PEI@siRNA showed a remarkable interference efficiency in the nerve cell line SK-N-SH and prevented the cells to be infected. The mechanism study revealed that Se@ PEI@siRNA could lighten the extent of SK-N-SH cells for staying in the sub-G1 phase. Activation of Bax apoptosis signaling was restrained either. Taken together, this study demonstrated that Se@PEI@siRNA is a promising drug against EV71 virus.
Herein, a facile and binder-free method was developed to prepare a flexible electrode for dual battery applications, which was achieved by fabricating nanosheets of ZnO-Co 3 O 4 heterostructures attached on the surface of highly conductive carbon cloth (CC). Remarkably, for Li-ion batteries, the combined effects of two dimensional (2D) heterostructural and three dimensional (3D) carbon fiber substrate offered an excellent reversible capacity rate of approximately 1785 mAh g −1 at a current density of 200 mA g −1 .Even at a charge-discharge rate of 2000 mA g −1 , the ZnO-Co 3 O 4 @CC composite exhibited a reversible capacity of 491 mAh g −1 after 400 cycles. For sodium-ion batteries, the composite exhibited a reversible specific capacity of 684 mAh g −1 at a current density of 200 mA g −1 and a capacity of 265 mAh g −1 after 500 cycles at a current density of 1000 mA g −1 . Flexible half-cells were also constructed, which exhibited high flexibility and excellent electrochemical performance. The excellent performance is mainly due to the in situ growth of ZnO-Co 3 O 4 nanosheets on the CC, which provided a large contact area between the active material and the flexible and conductive substrate, ultimately facilitating rapid electron transport and preventing the aggregation of large surface area nanosheets.
The MoS2–SnO2 heterostructures are encapsulated into carbon nanofibers via a simple and scalable process. The binder-free and robust structure exhibit high reversible capacity, long-term cycling stability, and excellent rate capability.
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