Enterovirus 71 (EV71) is the principal pathogen leading to severe cases of hand, foot, and mouth disease (HFMD). Specific drugs for EV71 are not discovered currently. Small interfering RNA (siRNA) provides a promising antiviral treatment pathway, but it is difficult to cross cell membranes and is easy to degrade. Nanoparticles are promising for their carrying capacity currently. In this study, the siRNA targeting EV71 VP1 gene was loaded with selenium nanoparticles (SeNPs) and surface decorated with polyethylenimine (PEI) (Se@ PEI@siRNA). Se@PEI@siRNA showed a remarkable interference efficiency in the nerve cell line SK-N-SH and prevented the cells to be infected. The mechanism study revealed that Se@ PEI@siRNA could lighten the extent of SK-N-SH cells for staying in the sub-G1 phase. Activation of Bax apoptosis signaling was restrained either. Taken together, this study demonstrated that Se@PEI@siRNA is a promising drug against EV71 virus.

No abstract

Herein, a facile and binder-free method was developed to prepare a flexible electrode for dual battery applications, which was achieved by fabricating nanosheets of ZnO-Co 3 O 4 heterostructures attached on the surface of highly conductive carbon cloth (CC). Remarkably, for Li-ion batteries, the combined effects of two dimensional (2D) heterostructural and three dimensional (3D) carbon fiber substrate offered an excellent reversible capacity rate of approximately 1785 mAh g −1 at a current density of 200 mA g −1 .Even at a charge-discharge rate of 2000 mA g −1 , the ZnO-Co 3 O 4 @CC composite exhibited a reversible capacity of 491 mAh g −1 after 400 cycles. For sodium-ion batteries, the composite exhibited a reversible specific capacity of 684 mAh g −1 at a current density of 200 mA g −1 and a capacity of 265 mAh g −1 after 500 cycles at a current density of 1000 mA g −1 . Flexible half-cells were also constructed, which exhibited high flexibility and excellent electrochemical performance. The excellent performance is mainly due to the in situ growth of ZnO-Co 3 O 4 nanosheets on the CC, which provided a large contact area between the active material and the flexible and conductive substrate, ultimately facilitating rapid electron transport and preventing the aggregation of large surface area nanosheets.

The free-standing CuOx–Co3O4@PNCNF anode delivers high specific capacity, rate capability, and cycling performance for lithium-ion batteries.

The MoS2–SnO2 heterostructures are encapsulated into carbon nanofibers via a simple and scalable process. The binder-free and robust structure exhibit high reversible capacity, long-term cycling stability, and excellent rate capability.

No abstract

Hierarchical ZSM-5 nanosheets with intracrystal mesopores and honeycomb morphology have been synthesised by seedinducing via a hydrothermal route in the presence of hexadecyl trimethyl ammonium bromide (CTAB) as the 10 30 Recently, MFI zeolite nanosheets were prepared by using designed bifunctional surfactant (C 22 H 45 -N + (CH 3 ) 2 -C 6 H 12 -N + (CH 3 ) 2 -C 6 H 13 ) as template, 4,16,17 however, the synthesis process of this template is very complex that the synthesise of MFI zeolite nanosheets becomes costly. Hierarchical ZSM-5 35 zeolite with house-of-card-like was synthesised with the assistance of N-Methyl-2-pyrrolidone (NMP). 18 Although NMP is one of common inexpensive solvents, it has environmental issues. Traditional surfactants CTAB as soft templates are of 40 † Electronic Supplementary Information (ESI) available: Detailed experimental procedures, SEM and TEM images of Hi-ZSM-5, ZSM-5 45 seeds and C-ZSM-5, nitrogen adsorption/desorption isotherms and BJH pore size distribution curves of Hi-ZSM-5, SEM images and FT-IR, XRD spectras of subnanocrystals, detailed product conversion, yield, selectivity and stability data See

The bifunctional Cs–La–Sb/SiO2 catalyst prepared by ultrasonic impregnation showed good catalytic performance and stability for the synthesis of methyl acrylate by aldol condensation of formaldehyde and methyl acetate.