We describe a catalyst-free visible-light mediated akynylperfluoroalkylation of unactive alkenes with perfluoroalkyl iodides, which provides a series of α-perfluoroalkyl-β-alkynyl ketone derivatives. This new synthetic protocol is enabled by a charge-transfer...
We have developed a transition-metal-free radical approach for 1,2-alkynyl functionalization of unactivated alkenes through the combination of 3-exo-dig cyclization with alkynyl migration triggered by in situ-generated diverse radical precursors. This strategy provides a robust toolkit to access a variety of synthetically important α-functionalized alkynyl ketones, simultaneously installing densely functionalized carbonyl, alkynyl, and other various functional groups into the alkenes. The broad substrate scope, which includes distinctly electron-donating or electronwithdrawing alkynyl migrating groups, excellent functional group compatibility, and remarkable selectivity make this protocol practical and attractive.
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