No abstract

Herein, we present a facile and efficient allylation method via Ni-catalyzed cross-electrophile coupling of readily available allylic acetates with a variety of substituted alkenyl brimides using zinc as the terminal...

A facile and efficient method is presented for the synthesis of 6‐alkylated phenanthridine, possessing hindered quaternary carbon centers, by Zn‐mediated reductive trapping of tertiary alkyl radicals with both electron‐rich and electron‐deficient aryl isocyanides using nickel as a promoter. Bench‐stable and operation‐friendly tertiary alkyl oxalates derived from abundant tertiary alkyl alcohols were first used as radical precursors for the alkylation of isocyanobiphenyl species. This reaction displays excellent functional group tolerance and broad substrate scope, allowing access to desired products in good to excellent yields.

This paper describes an efficient strategy to promote alkenyl thioetherifications via the Ni-catalyzed cross-coupling of inactivated or β-aryl-substituted (E)-alkenyl halides with thio-alcohols/phenols. The present strategy with easy-to-operate reaction conditions represents one of the most effective alkenyl C(sp2)–S bond-forming methods via readily accessible nickel catalysis. Notably, the mildly basic conditions employed facilitate access to a broad scope including protected amino acids, saccharides, and heterocycles. Moreover, this work presents its attractive usefulness by the application in late-stage modifications of several structurally complex natural products and pharmaceuticals.