Two reaction modes of 1-sulfonyl-1,2,3-triazoles and pyridinium 1,4-zwitterionic thiolates were described. Pyrido[1,2-a]pyrazine derivatives were obtained in moderate yields when 4-OEt substituted triazoles were employed in reactions, and 1,4-thiazine derivatives were...
A facile and metal‐free access to pyrazoles from 1,3‐diarylpropenes and hydrazines via multiple inter‐/intramolecular C‐H aminations was described. Under the neutral and mild 2,3‐dichloro‐5,6‐dicyanobenzoquinone (DDQ) oxidative conditions, various disubstituted pyrazoles were synthesized in moderate to excellent yields. This method provides a pot‐ and step‐economic strategy for the construction of pyrazoles, especially those for drug discovery.magnified image
A rhodium(II)-catalyzed [4 + 2] annulation of ester-tethered 1-sulfonyl-1,2,3-triazoles and hexahydro-1,3,5-triazines, which features a chemoselective 1,2-ester migration of α-imine rhodium carbene intermediates, has been developed. Most of the valuable 1,2,3,4-tetrahydropyrimidine derivatives were generated in good to excellent yields under mild conditions. Several important derivatization reactions have been performed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.