Two transition metal (Cu and Pd)-catalyzed C-S, C-N, and C-C bond cross-coupling reactions for the preparation of N-fused benzo[4,5]imidazo[2,1-b]thiazole derivatives were developed. A variety of 3-substituted and 2,3-disubstituted benzo[4,5]imidazo[2,1-b]thiazoles were efficiently and conveniently synthesized from the coupling reaction via trans-1,2-diiodoalkenes, 1H-benzo[d]imidazole-2-thiols, and halobenzenes in moderate to excellent yields.
A visible light-induced and metal-free strategy for the intermolecular three-compoment alkylpyridylation of styrenes is reported. Hantzsch ester was found to be key to initiate the overall reductive radical coupling reaction....
Rongalite has been used as a cheap and efficient carbon
synthon
for the synthesis of divergent N-heteroaromatics, including different
pyridines and quinolines. The selective synthesis of different products
can be achieved by employing enaminones or enaminones/anilines as
reaction partners. In addition, compared with the reaction using conventional
aldehyde synthons, rongalite displays an evident advantage in providing
products with considerably
higher product yields under milder conditions. The GC–MS analysis
of the reaction process has been performed to probe the possible reaction
mechanism.
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