Indolines are important moieties present in various biologically significant molecules and have attracted considerable attention in synthetic chemistry. This paper describes a sequential Heck reaction/C–H activation/amination process to form indoline with di-tert-butyldiaziridinone. The reaction process likely proceeds via a pallada(II)cycle, which is converted to an indoline by oxidative addition to the diaziridinone and subsequent double C–N bond formation.
Sulfur dots–graphene nanohybrids act as an efficient electrocatalyst for the conversion of N2 to NH3 in 0.5 M LiClO4, achieving a high NH3 yield of 28.56 μg h−1 mgcat.−1 and a Faradaic efficiency of 7.07% at −0.85 V vs. RHE.
The first asymmetric total syntheses of cladosporin and isocladosporin were accomplished in 8 steps with 8% overall yield and 10 steps with 26% overall yield, respectively. The relative configuration of isocladosporin was determined via this total synthesis.
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