An efficient palladium-catalyzed enantioselective isocyanide insertion/desymmetrizing C(sp 2 )−H bond activation reaction allowed by a SPINOL-derived phosphoramidite ligand was developed. 3,4-Dihydroisoquinolines containing C3 quaternary stereogenic centers were obtained in high yields with good enantioselectivity under mild conditions.
A general method to construct the scaffolds of dibenzooxazepine and dibenzodiazepine, through Pd-catalyzed isocyanide insertion and intramolecular C(sp 2 )−H activation, has been developed. This is the first example of sevenmembered heterocycle formation by C−H imidoylative annulation.
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