in Wiley Online Library (wileyonlinelibrary.com).Glucosamine hydrochloride 1 was treated with 1,3-dicarbonyl compounds to obtain 2-methyl-5-(1,2,3,4tetrahydroxy-butyl) pyrrole 2a and 2b, respectively. Under the role of NaIO 4 , 2a and 2b were successfully transformed into the related 5-formal pyrrole derivative 3a and 3b, respectively. Compounds 4a-4d and 5a-5e were obtained by reacting 3a and 3b with chlorinated hydrocarbons by alkylation reactions, respectively. The structures of all new products were confirmed by IR, NMR, and HRMS spectra.
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