A dilute dispersion containing small, force-free drops of one fluid dispersed in a second, immiscible in a linear flow field is considered for small Reynolds numbers and large Péclet numbers under isothermal conditions. The emphasis of our analysis is on the effects of pairwise drop interactions on their collision rate, as described by the collision efficiency, using a trajectory analysis. Simple shear flow and uniaxial extensional or compressional flow are considered. For both flows, the collision efficiency decreases with increasing drop viscosity due to the effects of hydrodynamic interactions. It also decreases as the ratio of the smaller drop radius to the larger radius decreases. For uniaxial flow, finite collision rates are predicted in the absence of interdroplet forces for all finite values of the drop size ratio and the ratio of the viscosities of the drop and suspending medium. In contrast, several kinds of relative trajectories exist for a pair of drops in simple shear flow, including open trajectories, collision trajectories, and closed and semi-closed trajectories, in the absence of interdroplet forces. When the ratio of small to large drop diameters is smaller than a critical value, which increases with increasing drop viscosity, all of the relative trajectories that start with the two drops far apart remain open (no collisions), unless in the presence of attractive forces. Attractive van der Walls forces are shown to increase the collision rates.

Elemental 2D materials with fascinating characteristics are regarded as an influential portion of the 2D family. Iodine is as a typical monoelemental molecular crystal and exhibits great prospects of applications. To realize 2D iodine, not only is it required to separate the weak interlayer van der Waals interactions, but also to reserve the weak intramolecular halogen bonds; thus, 2D iodine is still unexploited until now. Herein, atomically thin iodine nanosheets (termed “iodinene”) with the thickness around 1.0 nm and lateral sizes up to hundreds of nanometers are successfully fabricated by a liquid‐phase exfoliation strategy. When used for the cathode of rechargeable sodium‐ion batteries, the ultrathin iodinene exhibits superb rate properties with a high specific capacity of 109.5 mA h g−1 at the high rate of 10 A g−1 owing to its unique 2D ultrathin architecture with remarkably enhanced pseudocapacitive behavior. First‐principles calculations reveal that the diffusion of sodium ions in few‐layered iodinene changes from the original horizontal direction in bulk to the vertical with a small energy barrier of 0.07 eV because of the size effect. The successful preparation and intensive structural investigation of iodinene paves the way for the development of novel iodine‐based science and technologies.

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Partition of phenanthrene between water and roots was determined for 13 plant species using a batch equilibration technique. Partition coefficients (K rt ) from 734 to 2,564 L/kg were measured. A simple model to estimate the partition of organic contaminants between roots and water was developed based on the composition of plant roots and the 1-octanol/water partitioning coefficient. The estimates were close to the observed results, with differences of < 14%. The partition coefficients of phenanthrene by root cell walls were 13-84% greater than sorption by the corresponding roots. The cell wall fraction-the dominant fraction of root organic components-was identified as the primary domain for partition of phenanthrene. The measured hydroponic uptake of phenanthrene into roots was always less than phenanthrene partition by plant roots. A modified sorption model containing a quasi-equilibrium factor (α pt ) could reasonably predict hydroponic uptake by plant roots. The results obtained from this study provide insights into partition of highly lipophilic organic chemicals in roots, and provide convenient methods to estimate this partition as well as uptake of such chemicals in rootwater systems.

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Osteopontin (OPN) is associated with the severity and progression of osteoarthritis (OA); however, the mechanism of OPN in the pathogenesis of OA is unknown. In this study, we found that OA patients had higher abundance of OPN and matrix metalloproteinase 13 (MMP13). In chondrocytes, we showed that OPN promoted the production of MMP13 and activation of NF-κB pathway by increasing the abundance of p65 and phosphorylated p65 and translocation of p65 protein from cytoplasm to nucleus. Notably, inhibition of NF-κB pathway by inhibitor suppressed the production of MMP13 induced by OPN treatment. In conclusion, OPN induces production of MMP13 through activation of NF-κB pathway.

Pediatric cancers are the driving cause of death for children and adolescents. Due to safety requirements and considerations, treatment strategies and drugs for pediatric cancers have been so far scarcely studied. It is well known that tumor cells tend to progressively evade cell death pathways, which is known as apoptosis resistance, one of the hallmarks of cancer, dominating tumor drug resistance. Recently, treatments targeting nonapoptotic cell death have drawn great attention. Pyroptosis, a newly specialized form of cell death, acts as a critical physiological regulator in inflammatory reaction, cell development, tissue homeostasis and stress response. The action in different forms of pyroptosis is of great significance in the therapy of pediatric cancers. Pyroptosis could be induced and consequently modulate tumorigenesis, progression, and metastasis if treated with local or systemic therapies. However, excessive or uncontrolled cell death might lead to tissue damage, acute inflammation, or even cytokine release syndrome, which facilitates tumor progression or recurrence. Herein, we aimed to describe the molecular mechanisms of pyroptosis, to highlight and discuss the challenges and opportunities for activating pyroptosis pathways through various oncologic therapies in multiple pediatric neoplasms, including osteosarcoma, neuroblastoma, leukemia, lymphoma, and brain tumors.

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