Increased expression of STMN1 has been observed in many tumor forms, but its expression and potential biological role in pancreatic cancer is still unknown. In this study, we demonstrated that STMN1 was expressed to a large extent in pancreatic cancer tissues and cell lines as compared to normal pancreatic tissues. Suppression of STMN1 expression via transfection with STMN1-specific siRNA could not only significantly inhibit the proliferation, migration and invasion ability of Panc-1 cells, but also enhance the apoptosis of Panc-1 cells. In addition, downregulation of STMN1 obviously enhanced the acetylation level of α-tubulin. All these results indicated that STMN1 plays an important role in pancreatic cancer development, and might serve as a potential therapeutic target for pancreatic cancer.
Centrifugal experiments were carried out to investigate the stratum instability caused by the dissociation of gas hydrate. First gas hydrate-bearing sample was synthesized using biological anaerobic fermentation method. The silty sand was taken as the skeleton. Then four centrifugal experiments were carried out to study the responses of stratum to the dissociation of the gas hydrate. The characteristics of stratum slide and pore pressure variation and displacement were observed. It is shown that the produced gas can cause the increase of pore pressure and slope slide towards the toe during and after dissociation of gas hydrate. The failure occurs first at the toe of the sample and slides downwards along an arc sliding face. Cracks form at the top of the slope. The slope angle becomes smaller and smaller. This work is beneficial to the further study on the instability conditions of stratum due to the dissociation of gas hydrate.
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