A two-dimensional phase-detection system for a surface-plasmon-resonance sensor is presented. The sensor utilizes polarization interferometry to detect phase differences between the s and p polarizations. We successfully detected a spatial phase-difference variation, resulting from the biomolecular interactions, of less than 1 x 1 mm(2). The phase stability demonstrated in the experimental results was approximately 0.09 degrees, and the corresponding change in the refractive index detection limit was approximately 4.3 x 10(-6). The common-optical-path configuration of the proposed method allowed us to reduce disturbances from ambient conditions. Furthermore, this method is capable of real-time array detection.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.