Introduction: Coronavirus disease 2019 (COVID-19) has spread rapidly across the world. Given the sharply increased infection rate, the number of pregnant women and children with COVID-19 is correspondingly on the rise. SARS-CoV-2 infection is transmitted through droplets; though hypothesized, other transmission routes have not been confirmed. As of now, it remains unclear whether and how SARS-CoV-2 can possibly be transmitted from the mother to the fetus. Method: This study examines the medical records of 30 neonates born to women with COVID-19, the objective being to provide documented information on maternal-child transmission and infant outcomes. Results: Out of the 30 newborns, 28 had negative PCR test results for SARS-CoV-2; among their mothers, fifteen had fever, nine had cough and twenty had delivered by cesarean section. The median birth term was 37wk2dy, and twenty of the neonates were male. Most of them were asymptomatic, except for the three who presented with shortness of breath. Two of them were intubated and both died, the first because of severe sepsis and the second due to severe hyaline membrane disease. As regards the two infected neonates, the first represents a probable case of congenital SARS-CoV-2 infection, which appears unlikely in the second case. The outcome for both of them was good, without any complications. Conclusion: Maternal-fetal transmission of the SARS- CoV-2 virus was not detected in the majority of the reported cases, although two of 30 neonates had positive qRT-PCR test results. Our study supports the hypothesis that though it seldom actually occurs, in utero SARS-CoV-2 vertical transmission is possible.
Background: Although micronutrient supplementation is a frequent practice during pregnancy, it remains poorly documented, particularly in Algeria. Aims: Our objective was to assess the prevalence and factors associated with the use of micronutrient supplements among pregnant women. Subjects and Methods: The data of the present study were obtained from a cross-sectional survey conducted through a questionnaire among 384 pregnant women receiving prenatal care at a major mother and child specialized hospital in Sidi-Bel-Abbes city (Algeria). Results: This study showed that 83.1% of pregnant women were taking micronutrient supplements. Among these women, 70,8% were taking a multi-supplementation. The two most frequently reported micronutrients were: iron (77.9%) and folic acid (77.3%). The highest rates of supplementation were recorded in the third trimester. Other common supplements used were: magnesium, iodine, vitamin D, vitamin C, omega 3, and calcium (46.4%, 38.8% 36.5%, 34.6%, 27.3%, and 21.4% respectively). It appears that these products were mainly dispensed in pharmacies under medical prescription. The variables significantly associated with their use were: Education level, pregnancy age, parity, pre-conception consultation, urbanicity, and physical activity. Conclusions: Collecting these types of data is essential not only to document micronutrient supplement intake, but also to help implement awareness campaigns about their use during pregnancy and whether they are necessary to ensure adequate micronutrient intake. Keywords: Micronutrients, supplementation, Pregnancy, Algeria.
Introduction. Les effets indésirables médicamenteux sont devenus un défi important de la médecine moderne ; ils sont classés entre les quatrièmes et sixièmes causes principales de décès. Selon une étude conduite par Novotny et coll., les antibiotiques sont responsables de 16 % des effets indésirables enregistrés. Cette étude a pour objectifs de détecter, évaluer et d’analyser les effets indésirables liés à l’utilisation des antibiotiques au CHU de Sidi Bel-Abbès. Méthodes. Une étude prospective portant sur les malades du CHU de Sidi Bel-Abbès qui ont développé des effets indésirables liés à l’utilisation des antibiotiques pendant cinq mois (du 1er janvier au 30 mai 2014). Résultats. Un total de 73 effets indésirables a été signalé au cours de la période d'étude avec une prédominance masculine (53,42%) et le groupe d'âge gériatrique. Les organes les plus affectés étaient le système gastro-intestinal (34,24 %) et la peau (26,02 %). Les classes d'antibiotiques principalement comptabilisées étaient les céphalosporines (35,61 %), suivie par les fluoroquinolones (30,50 %) et (61,64 %) des effets indésirables étaient prévisibles. L'évaluation de la gravité a révélé que la plupart d'entre eux étaient modérés (65,75%), suivis par des réactions légères et graves. Conclusion. L'étude a conclu que le taux des effets indésirables est assez élevé, d’où la nécessité de la création d’un service de pharmacovigilance qui veille à la surveillance de ces effets et la mise en œuvre de directives d’antibiotiques à usage hospitalier afin d’assurer leur usage rationnel
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