Background: Both low-level laser therapy (LLLT) and platelet-rich plasma (PRP) are demonstrated to promote the repair of mandibular defects. Objectives: This study investigated the mechanical properties and calcium content at the tooth extraction site in a rat model exposed to LLLT (λ = 808 nm) with or without PRP. Methods: In this experimental rat model study, the left first molar maxillary teeth were extracted in twenty male rats. Then, the animals were randomly divided into four groups. Group one: after extraction, the extraction sockets were treated with 0.9 W gallium-aluminum-arsenide (GaAlAs) diode laser irradiation for five minutes every 72 hours for the next 12 days (4 times overall); group two: PRP was placed in the extraction sockets; group three: a combination of both treatments (LLLT+PRP) was applied; group four: the extraction sockets remained untreated (the control group). All rats were sacrificed 30 days post-operative. All bone blocks of the extracted socket were prepared for mechanical strength and calcium content analyses. Mann-Whitney test, one-way ANOVA test, and post hoc Fisher’s least significant difference (LSD) were used to analyze the data. A P-value less than 0.05 was considered significant. All analyses were performed by SPSS 16.0. The graph is illustrated in the graph pad 5. Results: The compressive strength in the laser group was significantly higher than in the control and PRP-treated groups (P = 0.0001 and 0.00044, respectively). Compared to the control and PRP groups, the effects of a combination of PRP and LLLT mechanical strength were statistically similar. Calcium content was influenced by none of the treatments. Conclusions: The mechanical strength of the bone blocks was significantly stronger in the LLLT group than in the other groups. PRP alone or combined with LLLT demonstrated a synergistic impact on neither mechanical strength nor calcium content.
Background: Both low-level laser therapy (LLLT) and platelet-rich plasma (PRP) have been suggested to improve the repair of mandibular defects. This study investigated the mechanical properties and calcium content at the tooth extraction site in the rat model exposed to LLLT (λ=808 nm) with or without PRP. Methods: In this experimental rat model, the maxillary left first molar teeth were extracted in twenty male rats. Then, they were divided randomly into four groups. Group one: the extraction sockets were treated by 0.9 W gallium-aluminum-arsenide (GaAlAs) diode laser irradiation for five minutes every 72 hours after extraction for the next 12 days (4 times in overall); group two: PRP was placed in the extraction sockets; group three: a combination of both treatments (LLLT+PRP) was done; group four: untreated extraction socket as the control group. All rats were sacrificed 30 days post-operative. All bone blocks of the extracted socket were prepared for mechanical strength and calcium content analyses. Results: The compressive strength in the laser group was significantly higher than in both the control and PRP-treated groups (p=0.0001 and 0.00044, respectively). Although a combination of both PRP and LLLT elevated the mechanical strength compared to the control and PRP groups, it was statistically similar to LLLT/PRP group. Calcium content did not change by any of the treatments. Conclusions: Mechanical and chemical analyses on the bone blocks demonstrated that LLLT improved bone healing; however, PRP alone or combined with LLLT did not show a synergistic impact.
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