An efficient and novel method was developed for the synthesis of 4-substituted-1,5-benzodiazepine derivatives via one-pot three-component catalytic reaction. The o-phenylenediamine and dimedone were reacted with aldehyde derivatives in the presence of ZnS nanoparticles as heterogeneous catalyst under thermal condition. The reaction was completed in high to excellent products yield and short reaction times. Simplicity of operation, high yields, easy work-up, accessible catalyst and purification of products 10 through crystallization method (non-chromatographic) are the key advantages of this work.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.