The prevalence of low vitamin D level in the studied healthy children was high and it is correlated with some components of metabolic syndrome. Outdoor activity for optimum sun exposure and additional studies are needed to evaluate the underlying metabolic syndrome components and hypovitaminosis D complications.

Ischemia/reperfusion (I/R) injury is a term used to describe phenomena connected to the dysfunction of various tissue damage due to reperfusion after ischemic injury.While I/R may result in systemic inflammatory response syndrome or multiple organ dysfunction syndrome, there is still a long way to improve therapeutic outcomes. A number of cellular metabolic and ultrastructural alterations occur by prolonged ischemia. Ischemia increases the expression of proinflammatory gene products and bioactive substances within the endothelium, such as cytokines, leukocytes, and adhesion molecules, even as suppressing the expression of other "protective" gene products

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Background and Objectives: Performing physical activity is one of the inexpensive and available interventions in the field of self-care of gestational diabetes. Changing and modifying health behaviors in individuals can lead to preventing or delaying the disease and its complications. The aim of this study was to determine the effect of physical activity counselling based on the theory of planned behavior (TPB) on glycemic indexes in women with gestational diabetes. Methods: In a randomized clinical trial, the effect of counselling based on TPB was investigated in 50 women with gestational diabetes. The eligible subjects were assigned to two groups (control and intervention) using randomized block design; then, glycemic indexes were measured (pre-and post-intervention). Data were analyzed using independent and paired t-test. Results: In this study, the mean FBS (p=0.028), hemoglobin A1C (p=0.008), 2-hour postprandial blood sugar (p=0.002) and the number of admission (p<0.001) in the intervention group decreased compared to the control group, and the mean physical activity at home (p<0.001), sports fields (p<0.001), transportation (p=0.015), tendency to physical activity (p<0.001), attitude toward physical activity (p<0.001), abstract norms (p=0.001) and perceived control (p<0.001) significantly increased. Conclusion: Considering the positive effects of intervention on controlling glycemic indexes, physical activity counseling can be considered as one of the effective strategies for controlling gestational diabetes, especially using health education theory.

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Introduction. Subclinical hypothyroidism during pregnancy can be associated with numerous adverse outcomes. The purpose of this study was to compare short-term adverse pregnancy outcomes in treated versus nontreated patients who fall within the numerical range of thyroid-stimulating hormone (TSH) between the Iranian and American reference ranges. Materials and Methods. Eighty pregnant women with a known level of antithyroid peroxidase (anti-TPO) and TSH levels of 2.5–3.9 mIu/L in the first trimester and 3–4.1 mIu/L in the second and third trimesters were enrolled in the study and randomly assigned into two groups including 41 patients in the intervention group and 39 in the control group. The intervention group was treated with levothyroxine at least 50 μg/day and the control group received no treatment. The data were analyzed by SPSS software version 23. Results. The only significant findings were a correlation between pregnancy loss frequency (p − 0.011) and/or increased TSH level in the follow-up period (p = 0.008) with anti-TPO antibody positivity. Forty-four percent of mothers with positive anti-TPO Ab needed treatment initiation with levothyroxine, based on Iranian guidelines, due to increased TSH level during the follow-up period. Conclusion. Untreated pregnant women with subclinical hypothyroidism, who were placed in the intermediate range of TSH, recommended by Iranian and American guidelines, did not show any significant difference in short-term adverse pregnancy outcomes compared to the treated patients. Positive anti-TPO Ab may play a role in the development of short-term complications in mothers with subclinical hypothyroidism or it may increase the likelihood of an increase in TSH level during pregnancy.

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The 2019 global Coronavirus syndrome pandemic (COVID-19) has entered more than two hundred countries around the world, involving <82 million persons and >1,800,000 deaths (until January, 1st 2021). We report on COVID-19 infection in the context of a Cushing's syndrome (CS) from Iran. A 36-year-old man with proximal myopathy, plethora, and striae with central obesity was evaluated for Cushing's syndrome. During the high dose dexamethasone test, the patient developed symptoms of cough, low-grade fever, and weakness then was admitted to the ICU with a diagnosis of COVID-19. Despite treatment according to national protocols for COVID-19, the patient unfortunately died. In this report, we intend to discuss the various aspects of Cushing's syndrome and severe COVID-19 infection.