A new
magnetic nanocomposite with a statistical star polymer structure
was designed and synthesized. Nanocomposite fabrication is based on
the polymerization of aromatic polyamide chains on the surface of
functionalized magnetic copper ferrite nanoparticles (CuFe2O4 MNPs). This magnetic nanostructure was characterized
by several analysis methods. All the analytical methods used, for
instance, Fourier transform infrared spectroscopy, energy-dispersive
X-ray spectroscopy, X-ray diffraction, thermogravimetric, vibrating-sample
magnetometer, and scanning electron microscopy (SEM), confirmed the
formation of polyamide chains. The obtained images from SEM imaging
showed a unique nanoflower morphology which was the proper orientation
results of synthesized nanoplates. Finally, the magnetic nanostructure
showed a good potential for hyperthermia applications, with a maximum
specific absorption rate of 7 W/g for 1 mg/mL of the sample under
a magnetic field in different frequencies (100, 200, 300, and 400
MHz) and 5 to 20 min time intervals.
Iron oxide nanoparticles (NPs) have been a very appealing choice in magnetic-mediated hyperthermia for cancer therapy. The responses of NPs to hyperthermia as a cancer treatment method are complex and variable. Herein, the heating properties of the casein-coated magnetic NPs (MNPs) under an alternating magnetic field were investigated. The casein-coated MNPs were synthesized via one-pot chemical method. The casein-coated MNPs were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDAX), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), zeta potential, dynamic light scattering (DLS), and vibrating sample magnetometer (VSM) analysis. TEM images of casein-coated MNPs show that their shapes are spherical and their core sizes are between 20[Formula: see text]nm and 25[Formula: see text]nm. The FTIR and EDAX results confirmed the presence of casein on the surface of MNPs. The VSM shows the superparamagnetic nature of iron oxide and casein-coated iron oxide NPs with the magnetic saturation of 60[Formula: see text]emu/g and 44.86[Formula: see text]emu/g, respectively, at room temperature. Furthermore, hyperthermia tests for casein-coated MNPs with various concentrations and frequencies are performed. Hyperthermia results show that lower concentrations of casein-coated MNPs dispatch higher heating into their surrounding medium, whereas maximum specific absorption rate occurs at the concentration of 1[Formula: see text]mg/mL for the frequency of 150[Formula: see text]kHz. Findings of this study suggest that casein-coated MNPs have great potential as an anticancer agent in hyperthermia cancer therapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.