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Purpose. To evaluate the short-term postoperative outcomes in endoscopic-assisted sclera fixation intraocular lens (IOL) for the management of secondary aphakia in children. Methods. This is a prospective study, whereas 40 aphakic eyes with absence of a good capsular support were implanted by endoscopy-assisted sclera fixation technique. Results. No major intraoperative complications were recorded. All cases were followed up for 6 months. Only transient ocular hypertension occurred in 10 (25%) eyes. Lens decentration and/or tilting were clinically detected in 2 eyes (5%). Ultrasonic biomicroscopic (UBM) examination revealed lens tilting in 2 (5%) of the operated eyes, despite the proper haptics positioning in the ciliary sulcus. Postoperative vitreous hemorrhage was reported in 5 eyes (12.5%) in the early postoperative period and retinal detachment in one eye. A postoperative refractive astigmatism ranging from 0.75 D to 3.75 D (mean 1.7 D ± 0.79) was recorded, as compared to mean preoperative values of 2.00 D, with no statistically significant differences being recorded (p ≥ 0.05). An improvement of BCVA, 1-2 lines on Snellen chart at the end of the follow-up period, was detected in 23 eyes (57.5%) with a mean of 0.6 ± 0.08 SD, as compared to a preoperative mean values of 0.5 ± 0.07 SD (p ≥ 0.05). Conclusion. Using an endoscope for transscleral suturing of intraocular lenses in aphakic pediatric eyes might be considered as being an effective technique that can reduce surgical complications, especially postoperative lens decentration.

Background: Background: Optic nerve inflammation may contribute to the pathology of multiple sclerosis (MS) (retrograde trans-synaptic degeneration) However, within the past ten years, some investigations have indicated that primary retinopathy may be brought on by MS. This study used a full-field electroretinogram to test the function of the outer retinal layers in people with relapsing remitting multiple sclerosis (RRMS) (ff-ERG). Methods: This is a case- control study, conducted on 30 RRMS patients and 30 healthy controls. RRMS patients were subjected to neurological, ophthalmological, and radiological assessment. Both RRMS patients and controls were subjected to full field ERG. Results: The ff-ERG showed a significant delay of latencies of a and b-waves of both light and dark-adapted condition with reduction of their amplitudes compared to control. ERG responses were significantly affected in MS patients with or without optic neuritis compared to control. Most of ff-ERG parameters showed non statistically significant difference between optic neuritis and non-optic neuritis eyes. Conclusion: There is functional affection of the bipolar and the photoreceptors layers in the outer retina in optic neuritis and non-optic neuritis eyes of MS. Therefore, the outer retina could be a site for primary pathology in MS, unrelated to the optic nerve affection.

Introduction Macular edema occurs in a wide variety of ocular diseases, and an alteration in the blood-retinal barrier (BRB) leads to the accumulation of fluid in the extracellular space and the development of fluid-filled (cystoid) spaces in the outer plexiform layer and the inner nuclear layer of the retina are common findings in cystoid macular edema (CME).. Aim of the Work : To evaluate the effect of intravitreal injection of ranibizumab on diabetic macular edema (DME). Patients and Methods Type of the study :A longitudinal descriptive randomized study.-Site of the study : The patients will be selected random from the outpatient clinic of National Eye Center of Opthamology in Rod El-Farag.-Date and period of study : This study was conducted in March 2019.-Size and type of sampling techniques to choose a representative sample: The study will include 20 eyes of 20 patients selected randomly with the following inclusion and exclusion criteria to receive a single intravitreal injection of ranibizumab.-20 eyes with Type II diabetes mellitus with non-proliferative diabetic retinopathy (NPDR) and significant focal or diffuse DME with no foveal serous detachment confirmed by OCT. Results: Twenty eyes attending the ophthalmic outpatient clinic between March 2019 and December 2019 were selected. They suffered focal or /and diffuse DME, All eyes received primary dose of intravitreal injection of ranibizumab (0.5 mg). Conclusion : The study showed that most patients did not show significant improvement in V/A rather than a significant decrease in central macular thickness after one injection and the improvement was considered less than those patients who had received multiple injections in other studies.

Background: OCT-A is developing as a new non-invasive rapid technique which may replace FFA as a gold standard procedure for diagnosis of DMI. Aim of the Work: Comparison between fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) for imaging of foveal avascular zone (FAZ) in diabetic retinopathy patients (DR) affected and not affected by diabetic macular ischemia, (DMI). Subjects and Methods: In this prospective study, 30 eyes for 30 patients and separated by macular status as 19 eyes with DMI and 11 eyes without DMI instructed to undergo OCT-A scan, FFA. Full ophthalmological examination was done and patients signed their informed consents. Results: Of the 30 patients, 13 females and 17 males with a mean age of 52.63 ± 11.9 years. 17 eyes with DMI and 13 eyes without DMI have underwent full ophthalmological examination, BCVA measurement, FFA and OCT-A. BCVA was higher among eyes without DMI (0.5 ±0.2) as compared with eyes with DMI (0.25 ±0.2). Mean time for FFA was 9.4 ± 3.2 m and for OCT-A was 1.5 ± 0.8 m. OCTA can save time than FFA by 85%. 57% was affected with artifacts with OCT-A while 7% has allergic reactions to flourescien dye. Subjects with DMI presented a mean area on FA and OCTA of 0.85 ± 0.2 mm 2 and 0.79± 0.2 mm 2 , respectively (p = 0.001). Patients without DMI presented a mean area on FA and OCTA of 0.39 ± 0.1 mm 2 and 0.36 ± 0.1 mm 2 , respectively (p = 0.01). The ICC for the FAZ measurements between the 2 observers on FA and OCTA was 0.98 and 0.99, respectively. Conclusion: OCTA represents a novel technique to diagnose DMI and it may become an alternative to FA for this purpose.