Present review shows, unexplained raised MSAFP level has high awareness, particularity, positive prescient worth and negative prescient worth in foreseeing unfavorable pregnancy result. Its estimation is effectively available and safe. • At mid-trimester, serum AFP might end up being more helpful assuming that it measure in blend with other biomarkers in distinguishing pregnancies at high gamble of early PE requiring conveyance < 32 weeks. Protein / creatinine proportion proportions are solid indicators of 24-hour pee in constant ailments. PATIENTS: Inclusion criteria: 1.Age group of <35 years. 2.Singleton pregnancies. 3.Gestational age of 22 weeks. 4.Known reliable last menstrual period. Exclusion criteria: 1.Patients with chronic medical diseases like diabetes, hypertension, chronic renal disease, hysteromyoma, antiphospholipidsyndrome, cystic salpinx, intrahepatic cholestasis of pregnancy and family history diseases. 2.Multiple pregnancy. 3.BMI <34 kg/m 2 .
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