The fundamental pattern of chewing induced by the network of neurons called central pattern generator has been reported
A group of cells exhibit uncontrolled proliferation, invasion, and occasionally metastasis in cancer, a category of disorders. According to statistics, cancer is the second largest cause of mortality in the world. As a result, current cancer research places a strong priority on the discovery and development of novel, effective, and selective anticancer medications. The purpose of this work was to determine the method by which Ehrlich ascites cancer (EAC) cells are inhibited by Co(II)-benzoin thiosemicarbazone complex in Swiss albino mice. DNA fragmentation assays and nuclear morphology observations both supported the induction of apoptosis in EAC cells. The mRNA expression levels of many tumor-related antiapoptotic genes, including B-cell lymphoma 2 (bcl-2), B-cell lymphoma extra-large (bcl-xL), and caspase-8, as well as proapoptotic genes, including p53 or tumor protein, bcl-2 associated X protein (bax), caspase-9, caspase-3, and poly-ADP ribose polymerase (PARP-1) and in vitro effect of caspase inhibitors on EAC cells. Using 2', 7'- dichlorodihydrofluorescein diacetate (DCFH-DA) staining, reactive oxygen species (ROS) production following Co(BTSC)2 treatment were quantified. The findings of this investigation revealed that the induction of apoptosis by Co(BTSC)2 occurred via an intrinsic mitochondria-mediated ROS-dependent mechanism as opposed to an extrinsic one, and that this intrinsic pathway was controlled by the bcl-2 protein family. As a result, this study offers support for conducting more research to develop novel anticancer drugs.
As Bangladesh is an agricultural country, irrigation water is an important factor in proper crop production. Thus irrigation water plays a vital role in food safety and security. This study, therefore, focuses on the estimation of the concentration of four heavy metals in irrigation water along with their pollution assessments. Twenty water samples were collected from different areas of Rajshahi City in Bangladesh. The concentration of heavy metals found in this study followed the order of Mn (0.0913-0.3701 mg/L) > Pb (0.0211-0.2104 mg/L) > Cd (0.0004-0.0222 mg/L) > Cr (0.00105-0.00937 mg/L). In a few cases, the concentrations of heavy metals exceed the permissible limit for irrigation water recommended by the Food and Agricultural Organization. Pollution assessments were carried out using the enrichment factor, geoaccumulation index, contamination factor, and modified degree of contamination. This study revealed that the enrichment factor for lead and chromium showed no enrichment, whereas cadmium showed minor to moderate enrichment, and manganese was used as a reference element. The geoaccumulation index and contamination factor demonstrate that lead and chromium were uncontaminated, but manganese and cadmium denote moderate contamination. The modified degree of contamination indicated nil to the lower degree of contamination for all samples. Therefore, awareness should be raised among the people about the adverse health effects of these metal contaminations. Proper steps by the government and different organizations should be taken to identify the reasons for their sources, and appropriate techniques should be implemented to reduce their concentrations.
Irrigation water is an important factor in proper crop production. Thus irrigation water plays a vital role in food safety and security. This study, therefore, focuses on the estimation of the concentration of four heavy metals in irrigation water along with their pollution assessments. The concentration of heavy metals found in this study followed the order of Mn (0.0913-0.3701 mg/L) > Pb (0.0211-0.2104 mg/L) > Cd (0.0004-0.0222 mg/L) > Cr (0.00105-0.00937 mg/L). In a few cases, the concentrations of heavy metals exceed the permissible limit for irrigation water recommended by the Food and Agricultural Organization. Pollution assessments were carried out using the enrichment factor, geoaccumulation index, contamination factor, and modified degree of contamination. This study revealed that the enrichment factor for lead and chromium showed no enrichment, whereas cadmium showed minor to moderate enrichment, and manganese was used as a reference element. The geoaccumulation index and contamination factor demonstrate that lead and chromium were uncontaminated, but manganese and cadmium denote moderate contamination. The modified degree of contamination indicated nil to the lower degree of contamination for all samples. Proper steps by the government and different organizations should be taken to identify the reasons for their sources, and appropriate techniques should be implemented to reduce their concentrations.
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