Oral gel formulations are known as easy to administer drug products for patients who have problems taking drugs including those with conditions such as dysphagia. In addition, there are numerous commercially available oral gel products, most of which are immediate-release formulation that release their pharmaceutical ingredient content by diffusion. This study is focused on developing oral gel formulations that reduce the dosing frequency and dosage compared to the conventional types. This is with the aim of facilitating the use of gel formulations for producing pharmaceutical agents with different dose regimens, thereby enhancing patient convenience. Here, we used naturally derived high-molecular-weight agar (Ag), xanthan gum (Xa), and locust bean gum (Lo) as gel bases to prepare a variety of gel membranes, and evaluated the diffusion coefficient of the model substances. The result revealed that the Ag content in the Xa-Lo combination gel concentrationdependently increased the diffusion coefficient. Moreover, these findings were applied in an attempt to mask the taste of intensely bitter levofloxacin. The results indicated that the Xa-Lo combination gel exhibited a significantly superior masking effect to that of the Ag gel. This study demonstrates the feasibility of using oral gel formulations to modulate the controlled-release functionality of pharmaceutical agents.Key words oral gel formulation; diffusion control; time lag method; naturally derived high-molecular-weight gel; dissolution profileIn recent years, proactive development of formulations that facilitate patient convenience in taking medicines has been encouraged to improve drug compliance and adherence. Examples of such efforts include orally disintegrating tablets, 1,2) film drug products, 3,4) and oral gel formulations. 5,6) The increasing trend of proactive research and development into these formulations may have been partly encouraged by a rapidly growing aging population worldwide. In particular, Japan is currently experiencing a situation where our population appears to enter into the phase of an aged society ahead of the rest of the world. This circumstance makes addressing the challenges for the prevention of diseases such as pneumonia aspiration associated with compromised swallowing functions in aged people a priority.Current research on oral gel products has focused on easeof-dosing that can be achieved by the proper flowability and easy chewability offered by gel formulations. Furthermore, these formulations can clinically enhance drug compliance in the elderly and patients with dysphagia and, therefore, they were primarily expected to be used in hospital dispensaries. However, advances in manufacturing machinery and technologies in recent years have gradually encouraged active research into gel formulations with a post-marketing projection. The beneficial effects of some oral gel formulation jellies have been demonstrated including Caloryl ® that contains lactulose as a hyperammonemia treatment drug; Lagnos ® , Argamate ® that contain...