The in vitro gluten challenge test can be a useful part of the diagnostic workup of CD, rather than only a model to evaluate its mechanisms.
Introduction: Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple beneficial effects on glucose and lipid homeostasis and insulin sensitivity. Objectives: The aim of this study was to investigate the relation between the serum level of FGF21 with and metabolic syndrome (MS) in kidney transplant recipients. Patients and Methods: We performed a cross-sectional study on 86 stable renal transplant recipients to detect possible relation between serum FGF21 level and MS during October 2014 and Mach 2015. Patients with past history of diabetes mellitus were excluded. Results: There were 43 patients in each group with and without MS. Totally, they were 52 (60.5%) male and 34 (39.5%) female. The mean age of the MS group was significantly higher than that of non-MS group. There was not significant difference between mean serum creatinine level and glomerular filtration rate (GFR) between two groups (P > 0.05). The MS patients had higher weight and body mass index (BMI) (P < 0.05). The prevalence of BMI >25 kg/m2 in MS group was 25 (58.8%) versus non-MS group that only 10 (23.3%) had this condition (P < 0.05). The mean of FGF21 level in MS and non-MS groups was 1.23 ± 0.67 ng/l and 1.18 ± 0.71 ng/l, respectively (P > 0.05). There was not significant difference of serum FGF21 level between MS and non-MS patients (P > 0.05). Conclusion: While the elevated serum FGF21 level was found in subjects with insulin resistant states, however, this study revealed that serum FGF21 levels were not significantly increased in renal transplanted recipients with MS as compared with non-MS group.
Abstracts hospitalization, while the remaining 57 (41.4%) were followed-up as outpatients. The control group consisted of 61 healthy children. Patients with CAP had lower MPV values than their healthy counterparts (7.14±0.70 vs. 8.35±1.26 fL; p<0.001). Following ROC analysis, the cut-off value established for MPV was 8.05, which had a sensitivity of 91% and a specificity of 51% for making a diagnosis of CAP. Patients with severe CAP that required hospitalization had significantly higher CRP levels than those who were followed-up on an outpatient basis (p<0.001). Conclusions Our findings suggest that MPV could be used for the diagnosis of CAP in children. Subacute sclerosing panencephalitis (SSPE) is devastating progressive neurodegenerative disorder of the central nervous system by an aberrant measles virus. SSPE is still important health problem in countries where measles immunization is incomplete and in world regions where genetic polymorphism to this particular infection is present. We aimed to make a retrospective analysis of the clinical and laboratory findings and prognostic factors of children with SSPE. Method A total 55 consecutive cases (22 female, 33 male), aged 5-19 years, followed-up for SSPE at the Pediatric Neurology Department were included. The risk factors for progression time of SSPE from stage I-II to IV according to the criteria of Jabbour examined were gender, age at diagnosis of SSPE, presence of neuroimaging abnormalities, age of patient during measles infection and the antibody index for measles. SSPE risk factors were obtained through a questionnaire via personal interviews and the medical records and were assessed using Mann-Whitney U, Student t and Pearson correlation tests. Results Presence of neuroimaging abnormalities, gender, age at diagnosis of SSPE, presence of neuroimaging abnormalities, age of patient during measles infection and the antibody index for measles were not associated with a progressive clinical deterioration (p>0.05). 66.7 percent of cases were vaccinated with measles vaccine, 43.5 percent of cases have had measles infection before age of 9 months. Conclusion Viral, host and environmental factors are probably involved in the development and progression of SSPE. Successful measles vaccination programmes which accordance with the requirements of that country can protect the population against SSPE. Background and Aim A broad range of neurologic disorders have been described in children with Lyme disease. In contrast, there are few reports of transverse myelitis in pediatric Lyme disease patients. Case Report A 12-old girl admitted with the complaints of weakness in legs, sensory loss in lower limb, and backache for 10 days. Mental status, cranial nerve, and upper-extremity motor and sensory examinations produced normal results. The strength in his iliopsoas and hamstring muscles was scored 2/5. Deep tendon reflexes AN ANALYSIS OF THE ACUTE TRANSVERSE MYELITIS IN
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