The rise of antibiotic-resistant microorganisms has become a critical issue in recent years and has promoted substantial research efforts directed to the development of more effective antimicrobial therapies utilizing different bactericidal mechanisms to neutralize infectious diseases. Modern approaches employ at least two mixed bioactive agents to enhance bactericidal effects. However, the combinations of drugs may not always show a synergistic effect, and further, could also produce adverse effects or stimulate negative outcomes. Therefore, investigations providing insights into the effective utilization of combinations of biocidal agents are of great interest. Sometimes, combination therapy is needed to avoid resistance development in difficult-to-treat infections or biofilm-associated infections treated with common biocides. Thus, this contribution reviews the literature reports discussing the usage of antimicrobial polymers along with nanomaterials or other inhibitors for the development of more potent biocidal therapies.
In this communication, γ‐phenyl‐γ‐butyrodithiolactone (DTL1) is presented as the first example of a new type of control agent. The styrene polymerization carried out at 60 °C in the presence of DTL1 exhibits living characteristics, without consuming DTL1 during the process. This unprecedented behavior was explained by a mechanism based on the reversible formation of a persistent radical adduct between the DTL1 and the polystyrene macroradicals.magnified image
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