In order to elucidate the fate of nitrosoamines in the body, the title compounds (3) have been synthesized from the compounds (1) and (2). Xenobiotics are known to be hydroxylated in the organism and, bound to glucuronic acids, excreted. However, compounds such as (3) may also be transport forms.
A scheme is developed for synthesizing 14C labelled α‐acetates of secondary α‐hydroxylated nitrosamines. In this manner 14C‐methyl (1‐acetoxy)ethyl nitrosamine and 1‐14C‐ethyl (1‐acetoxy)ethyl nitrosamine are synthesized in 16.3 and 33.3% yield, radiochemically pure.
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