Microorganisms facilitate the formation of a wide range of minerals that have unique physical and chemical properties as well as morphologies that are not produced by abiotic processes. Here, we report the production of an extensive extracellular network of filamentous, arsenic-sulfide (As-S) nanotubes (20 -100 nm in diameter by Ϸ30 m in length) by the dissimilatory metal-reducing bacterium Shewanella sp. HN-41. The As-S nanotubes, formed via the reduction of As(V) and S2O3 2؊ , were initially amorphous As2S3 but evolved with increasing incubation time toward polycrystalline phases of the chalcogenide minerals realgar (AsS) and duranusite (As4S). Upon maturation, the As-S nanotubes behaved as metals and semiconductors in terms of their electrical and photoconductive properties, respectively. The As-S nanotubes produced by Shewanella may provide useful materials for novel nano-and opto-electronic devices. N anotubes are considered critically important building blocks for the production of nanodevices because of their high aspect ratios and unique size-dependent properties (1-3). The former property makes them useful for integration into highdensity devices, and the latter, which diverges from the bulk because of quantum confinement effects, helps adjust the electrical and optoelectronic properties by controlling their dimensions for specific applications. Since the first discovery of carbon nanotubes in 1991 (4), there has been growing interest in synthesizing diverse inorganic nanotubes, nanowires, and nanofilms, including metal dichalcogenides, MX 2 (M ϭ Mo, W, Nb, Hf; X ϭ S, Se), which are known to be photoconductive and sensitive to the near-optical-band-gap illumination (5-9). Although chalcogenide As 2 S 3 glasses (bandgap ϭ 2.35 eV) are important infrared (IR) transparent materials that have been used in many applications, including waveguides, photonic crystals, sensors, and photolithography (10), there have been no reports of nanotube structures made of arsenic-sulfide that have useful nano-and optoelectronic properties.Microorganisms play an essential role in the biogeochemical cycling of elements and in the formation of unique minerals (11)(12)(13)(14). Biogenic minerals are often formed in the nanometer scale through diverse microbiologically mediated physiological and metabolic activities and by passive surface reactions on cell walls or extracellular structures. They have unique chemical and physical properties (15, 16) as well as diverse morphologies (17, 18) that are not easily duplicated by means of strictly abiotic or synthetic reactions (16). Bacterial dissimilatory metal reduction, for example, can result in the biogenesis of diverse minerals, such as magnetite (Fe 3 O 4 ) (19,20) and uraninite (UO 2 ) (21, 22), with unique nanometer-size domains. Because of their small size and large specific surface area, biogenic nanoparticles have found wide use in various medical, biotechnological, chemical, and electronic applications (23).It was thought that As 2 S 3 (orpiment) was formed by abiological...