The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed protein that contains both an ion channel and an active kinase. TRPM7 has involved in a variety of cellular functions and critically participates in various diseases mainly including cancer and neurodegenerative disorders. However, the theme trends and knowledge structures for TRPM7 have not yet been studied bibliometrically. The main purposes of this research are to compare the scientific production in the research field of TRPM7 among countries and to evaluate the publication trend between 2004 and 2019. All publications were extracted from the Web of Science Core Collection (WoSCC) database from 2004 to 2019. Microsoft Excel 2018, Prism 6, and CiteSpace V were applied to analyze the scientific research outputs including journals, countries, territories, institutions, authors, and research hotspots. In this report, a total of 860 publications related to TRPM7 were analyzed. Biophysical Journal ranked top for publishing 31 papers. The United States of America had the largest number of publications (320) with a high citation frequency (11,298) and H-index (58). Chubanov V (38 publications) and Gudermann T (38 citations), who from Ludwig Maximilian University of Munich, were the most productive authors and had the greatest co-citation counts. Our study also combined the bibliometric study with a systematic review on TRPM7, highlighting the four research frontiers of TRPM7. This is the first study that demonstrated the trends and future development in TRPM7 publications, providing a clear and intuitive profile for the contributions in this field.

Graphical abstract Cholesterol reduces TMEM16A expression via DNMT1-mediated promoter methylation and directly inhibits channel activities. TMEM16A inhibition promotes endothelial angiogenesis.

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Soil phosphorus accumulation resulting in a high risk of phosphorus pollution is due to high multiple vegetable cropping indexes and excessive fertilizer input in protected fields. Therefore, this study explored the bioavailability of soil-accumulated phosphorus to improve fertilization and reduce the risk of soil phosphorus contamination in protected fields. A field trial was performed in Yanbian Prefecture, China to study the phosphorus bioavailability after continuous spinach planting without phosphate fertilizer applications. Results indicated that with increasing numbers of planting stubbles, soil inorganic phosphorus and occluded phosphorus changed little, while water-soluble and loose phosphorus, aluminum-phosphate, iron-phosphate, and calcium-phosphorus decreased first and then increased. Soil available phosphorus declined linearly. For planting spinach in protected fields, the threshold of soil phosphorus deficiency is 200 mg kg−1. A soil phosphorus supply potential model was established between x (the soil available phosphorus) and y (the numbers of planting stubbles): y = 6.759 + 0.027x, R = 0.99, which can be used to predict how planting stubbles are needed to raise the soil available phosphorus above the critical value of phosphorus deficiency for spinach. These results will provide the theoretical guidance for rational phosphorus fertilizer applications and control agricultural, non-point pollution sources in protected fields.