The solubility and absorption rate of carbon dioxide into monoethanolamine/ piperazine/water were measured in a wetted wall column at 40-60°C. The total amine concentration was varied from 1.0 M to 5.0 M with monoethanolamine blends containing 0 to 1.2 M piperazine. CO 2 solubility and solution speciation were simulated by nine equilibrium reactions. Two of the equilibrium constants were adjusted to match literature data. The rate of absorption was predicted by the theory of diffusion with fast chemical reaction. Piperazine at 24 mol% of the total amine decreases CO 2 equilibrium pressure by 50% and enhances CO 2 absorption rate by 50% to 100%. The CO 2 enhancement factor decreases by an order of magnitude as loading increases from 0 to 0.5 moles CO 2 /mole amine.
Synthesis of an aldehyde acrylate-based functional monomer and incorporation into poly(N-isopropylacrylamide-co-methacrylic acid) nanogels for use as high pI protein receptors.
The solubility and absorption rate of carbon dioxide into monoethanolamine/ piperazine/water were measured in a wetted wall column at 40-60°C. The total amine concentration was varied from 1.0 M to 5.0 M with monoethanolamine blends containing 0 to 1.2 M piperazine. CO 2 solubility and solution speciation were simulated by nine equilibrium reactions. Two of the equilibrium constants were adjusted to match literature data. The rate of absorption was predicted by the theory of diffusion with fast chemical reaction. Piperazine at 24 mol% of the total amine decreases CO 2 equilibrium pressure by 50% and enhances CO 2 absorption rate by 50% to 100%. The CO 2 enhancement factor decreases by an order of magnitude as loading increases from 0 to 0.5 moles CO 2 /mole amine.
Although dry eye is highly prevalent, many challenges exist in diagnosing the symptom and related diseases. For this reason, anionic hydrogel-coated gold nanoshells (AuNSs) were used in the development of a label-free biosensor for detection of high isoelectric point tear biomarkers associated with dry eye. A custom, aldehyde-functionalized oligo(ethylene glycol)acrylate (Al-OEGA) was included in the hydrogel coating to enhance protein recognition through the formation of dynamic covalent (DC) imine bonds with solvent-accessible lysine residues present on the surface of select tear proteins. Our results demonstrated that hydrogel-coated AuNSs, composed of monomers that form ionic and DC bonds with select tear proteins, greatly enhance protein recognition due to changes in the maximum localized surface plasmon resonance wavelength exhibited by AuNSs in noncompetitive and competitive environments. Validation of the developed biosensor in commercially available pooled human tears revealed the potential for clinical translation to establish a method for dry eye diagnosis.
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