A visible-light-mediated protocol for the hydroacylation of azobenzenes with α-keto acids has been developed. In the absence of any catalyst or additive, decarboxylative hydroacylation proceeded smoothly under visible-light irradiation at room temperature. A wide range of azobenzenes and α-keto acids were well-tolerated and afforded hydroacylation products in high to excellent yields. Preliminary investigations indicated that photoactive azobenzenes absorb visible light to enable the transformation.
A visible-light-promoted
transfer hydrogenation of azobenzenes
has been developed. In the presence of B2pin2 and upon visible-light irradiation, the reactions proceeded smoothly
in methanol at ambient temperature. The azobenzenes with diverse functional
groups have been reduced to the corresponding hydrazobenzenes with
a yield of up to 96%. Preliminary mechanistic studies indicated that
the hydrogen atom comes from the solvent and the transformation is
achieved through a radical pathway.
A visible-light-mediated α-hydroxylation of α-methylene ketones using atmospheric oxygen as a green oxidant has been developed with novel substrate selectivity.
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