Highlights
UCA1 is upregulated in both osteosarcoma tissues and cell lines.
UCA1 promotes osteosarcoma metastasis both
in vitro
and
in vivo.
UCA1 increased CREB1 expression by functioning as a ceRNA of CREB1 against miR-582.
The pro-metastasis role of UCA1 is achieved by promoting EMT.
UCA1 enhances EMT through CREB1-mediated the PI3K/Akt/mTOR pathway.
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