Purpose: To compare the postoperative outcomes between Akreos MI60 and Akreos AO intraocular lens (IOLs) after cataract surgery. Methods: A prospective analysis among 55 eyes of 55 patients who had undergone microcoaxial phacoemulsification and implantation of aspheric IOLs (Akreos MI60, 30 eyes; Akreos Adapt-AO, 25 eyes) was performed. The best corrected visual acuity (BCVA), spherical equivalent, intraocular pressure (IOP), corneal thickness, endothelial cell density (ECD), surgically induced astigmatism (SIA), predictability of postoperative spherical equivalent, higher order aberrations, and contrast sensitivity test were evaluated during the follow-up period of 3 months. Results: There were no significant differences in BCVA, spherical equivalent, IOP, corneal thickness, ECD, SIA, higher order aberrations and contrast sensitivity test (p>0.05). The predictability of postoperative spherical equivalent in the Akreos Adapt-AO (-0.57±0.22D) represented statistically significant myopic shift compared with the Akreos MI60 group (-0.05±0.69D) (p=0.02). Conclusions: Both the Akreos MI60 and the Akreos Adapt-AO implantation groups performed similiarly, following cataract surgery, showed similar visual function.
Purpose: To compare the visual function and postoperative refraction between two aspheric intraocular lenses (IOLs) after microcoaxial cataract surgery. Methods: A prospective analysis of 60 eyes of 58 patients who had undergone microcoaxial phacoemulsification and implantation of aspheric IOLs (AcrySof IQ, 30 eyes; Akreos MI60, 30 eyes) was performed. The best corrected visual acuity (BCVA), spherical equivalent, intraocular pressure (IOP), corneal thickness, endothelial cell density (ECD), predictability of postoperative spherical equivalent, higher order aberrations, contrast sensitivity test, satisfaction, and glare were evaluated during the follow-up period of three months. Results: There were no significant differences in BCVA, spherical equivalent, IOP, corneal thickness, or ECD (p>0.05). The predictability of the postoperative spherical equivalent in the AcrySof IQ and Akreos MI60 IOL groups was not significantly different (p=0.59), and the two groups showed good anterior-posterior stability during the postoperative three months. There were no significant differences in higher order aberrations, contrast sensitivity test, satisfaction or glare (p>0.05). Conclusions: Both AcrySof IQ and Akreos MI60 implantation groups showed similar visual functions and postoperative spherical equivalents after microcoaxial cataract surgery.
= Abstract =Objectives: Osteoclasts are multinucleated giant cells which can resorb bone and differentiated from hematopoietic cells. We have previously reported murine osteoclast-associated receptor (OSCAR) may be an important bone-specific regulator of osteoclast differentiation. We have cloned soluble form of human OSCAR (hOSCAR) and examined the role of hOSCAR on osteoclast differentiation. Methods: Osteoclast differentiation was induced by treatment with macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa B ligand (RANKL) and tartrate-resistant acid phosphatase (TRAP) staining and pit formation were performed. Expression was measured by flow cytometry analysis, Northern and Western blot analysis.
Results: hOSCAR is expressed in osteoclast cells and involved in the differentiation of osteoclasts from peripheral blood mononuclear cells (PBMC). Two alternatively spliced forms (soluble hOSCAR [hOSCAR-S]) of hOSCARwere identified from osteoclasts complementary deoxyribonucleic acid (cDNA) library derived from PBMC. Putative transmembrane domain was not found in hOSCAR-S forms and it suggested that these forms might be secreted from osteoclast cells. These secreted forms of hOSCAR attenuated RANKL-induced osteoclast formation and bone resorption. Conclusions: Human osteoclasts express at least five different OSCAR messenger ribonucleic acid (mRNA) isoforms which could play different regulatory roles for differentiation. The secreted forms of hOSCAR might be a negative regulator of membrane-bounded forms of OSCAR.
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