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Today's data networks are surprisingly fragile and difficult to manage. We argue that the root of these problems lies in the complexity of the control and management planes-the software and protocols coordinating network elements-and particularly the way the decision logic and the distributed-systems issues are inexorably intertwined. We advocate a complete refactoring of the functionality and propose three key principles-network-level objectives, network-wide views, and direct control-that we believe should underlie a new architecture. Following these principles, we identify an extreme design point that we call "4D," after the architecture's four planes: decision, dissemination, discovery, and data. The 4D architecture completely separates an AS's decision logic from protocols that govern the interaction among network elements. The AS-level objectives are specified in the decision plane, and enforced through direct configuration of the state that drives how the data plane forwards packets. In the 4D architecture, the routers and switches simply forward packets at the behest of the decision plane, and collect measurement data to aid the decision plane in controlling the network. Although 4D would involve substantial changes to today's control and management planes, the format of data packets does not need to change; this eases the deployment path for the 4D architecture, while still enabling substantial innovation in network control and management. We hope that exploring an extreme design point will help focus the attention of the research and industrial communities on this crucially important and intellectually challenging area.

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The invariant development and transparent body of the nematode Caenorhabditis elegans enables complete delineation of cell lineages throughout development. Despite extensive studies of cell division, cell migration and cell fate differentiation, cell morphology during development has not yet been systematically characterized in any metazoan, including C. elegans. This knowledge gap substantially hampers many studies in both developmental and cell biology. Here we report an automatic pipeline, CShaper, which combines automated segmentation of fluorescently labeled membranes with automated cell lineage tracing. We apply this pipeline to quantify morphological parameters of densely packed cells in 17 developing C. elegans embryos. Consequently, we generate a time-lapse 3D atlas of cell morphology for the C. elegans embryo from the 4- to 350-cell stages, including cell shape, volume, surface area, migration, nucleus position and cell-cell contact with resolved cell identities. We anticipate that CShaper and the morphological atlas will stimulate and enhance further studies in the fields of developmental biology, cell biology and biomechanics.

Coordination of cell division timing is crucial for proper cell fate specification and tissue growth. However, the differential regulation of cell division timing across or within cell types during metazoan development remains poorly understood. To elucidate the systems-level genetic architecture coordinating division timing, we performed a high-content screening for genes whose depletion produced a significant reduction in the asynchrony of division between sister cells (ADS) compared to that of wild-type during Caenorhabditis elegans embryogenesis. We quantified division timing using 3D time-lapse imaging followed by computer-aided lineage analysis. A total of 822 genes were selected for perturbation based on their conservation and known roles in development. Surprisingly, we find that cell fate determinants are not only essential for establishing fate asymmetry, but also are imperative for setting the ADS regardless of cellular context, indicating a common genetic architecture used by both cellular processes. The fate determinants demonstrate either coupled or separate regulation between the two processes. The temporal coordination appears to facilitate cell migration during fate specification or tissue growth. Our quantitative dataset with cellular resolution provides a resource for future analyses of the genetic control of spatial and temporal coordination during metazoan development.