Achieving the activation of drugs within cellular systems may provide targeted therapies. Here we construct a tumour-selective cascade activatable self-detained system (TCASS) and incorporate imaging probes and therapeutics. We show in different mouse models that the TCASS system accumulates in solid tumours. The molecules show enhanced accumulation in tumour regions via the effect of recognition induced self-assembly. Analysis of the molecular penetration in tumour tissue shows that in vivo self-assembly increases the penetration capability compared to typical soft or hard nanomaterials. Importantly, the in vivo self-assembled molecules exhibit a comparable clearance pathway to that of small molecules, which are excreted from organs of the reticuloendothelial system (liver and kidney), while are relatively slowly eliminated from tumour tissues. Finally, this system, combined with the NIR probe, shows high specificity and sensitivity for detecting bladder cancer in isolated intact patient bladders.
Tumor complexity makes the development of highly sensitive tumor imaging probes an arduous task. Here, we construct a peptide‐based near‐infrared probe that is responsive to fibroblast activation protein‐α (FAP‐α), and specifically forms nanofibers on the surface of cancer‐associated fibroblasts (CAFs) in situ. The assembly/aggregation‐induced retention (AIR) effect results in enhanced accumulation and retention of the probe around the tumor, resulting in a 5.5‐fold signal enhancement in the tumor 48 h after administration compared to that of a control molecule that does not aggregate. The probe provides a prolonged detectable window of 48 h for tumor diagnosis. The selective assembly of the probe results in a signal intensity over four‐ and fivefold higher in tumor than in the liver and kidney, respectively. With enhanced tumor imaging capability, this probe can visualize small tumors around 2 mm in diameter.
In existing literature ,there is no unified time for the evaporating excessive acid to microwave digestion solution of different samples. a new method was developed .The interference from nitrite ion and volatile nitrogen oxides which were generated during digestion were quickly removed by the adding urea and heating with boiling water. The interference from nitrate was studied. Optimized conditions of determination of arsenic with hydride generation atomic absorption spectrometry. The detection limit was 0.3μg·L-1 and minimum quantitative detection limit was 1.0μg·L-1, the relative standard deviation of standard addition method in sample was 1.1% and recovery from 98 % to 102%.
With accelerating urbanization construction, especially with the scale enlargement of high-rise buildings, the crane’s hoist boom length and height is increasing.The hoist boom will produce strength and buckling failure easily on the working condition of complex combination, such as gravity, wind load and inertia force.The TC6010 crane was analyzed the mechanics by finite element method. This thesis got its stability and strength data in four kinds of working conditions. It can provide certain reference value for other crane’s design and calculation.
China has been the country which is suffering serious coastal erosion that primarily caused by the increase of hydrodynamic force and the unbalance between input and output sediment. Comparing with the traditional revetment, most of which were made of reinforced concrete, the ecological shoreline protection can prevent coastal erosion in an ecological method. In this article, a biodegradable coastline protection mat (BCP-mat) was proposed and different arrangement methods direct to various areas was presented to solve the problems such as high cost, complicated construction caused by existing ecological method. In the end, the existing technology problems and promotion difficulties was discussed in the perspective of design and management.
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