We have studied the evolution of the photospheric magnetic Ðeld in active region NOAA 8668 for 3 days while the formation of a reverse S-shaped Ðlament proceeded. From a set of full-disk line-of-sight magnetograms taken by the Michelson Doppler Imager (MDI) on board the Solar and Heliospheric Observatory (SOHO), we have found a large canceling magnetic feature that was closely associated with the formation of the Ðlament. The positive Ñux of the magnetic feature was initially 1.5 ] 1021 Mx and exponentially decreased with an e-folding time of 28 hr throughout the period of observations. We also have determined the transverse velocities of the magnetic Ñux concentrations in the active region by applying local correlation tracking. As a result, a persistent pattern of shear motion was identiÐed in the neighborhood of the Ðlament. The shear motion had a speed of 0.2È0.5 km s~1 and fed negative magnetic helicity of [3 ] 1042 Mx2 into the coronal volume during an observing run of 50 hr at an average rate of [6 ] 1040 Mx2 hr~1. This rate is an order of magnitude higher than the rate of helicity change due to the solar di †erential rotation. The magnetic Ñux of the Ðeld lines created by magnetic reconnection and the magnetic helicity generated by the photospheric shear motion are much more than enough for the formation of the Ðlament. Based on this result, we conjecture that the Ðlament formation may be the visible manifestation of the creation of a much bigger magnetic structure that may consist of a Ñux rope and an overlying sheared arcade.

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Recent advances in the lab-on-a-chip field in association with nano/microfluidics have been made for new applications and functionalities to the fields of molecular biology, genetic analysis and proteomics, enabling the expansion of the cell biology field. Specifically, microfluidics has provided promising tools for enhancing cell biological research, since it has the ability to precisely control the cellular environment, to easily mimic heterogeneous cellular environment by multiplexing, and to analyze sub-cellular information by high-contents screening assays at the single-cell level. Various cell manipulation techniques in microfluidics have been developed in accordance with specific objectives and applications. In this review, we examine the latest achievements of cell manipulation techniques in microfluidics by categorizing externally applied forces for manipulation: (i) optical, (ii) magnetic, (iii) electrical, (iv) mechanical and (v) other manipulations. We furthermore focus on history where the manipulation techniques originate and also discuss future perspectives with key examples where available.

Abstract. In the present work, the dominant hemisphere of solar activity in each of solar cycles 12 to 22 has been clarified by calculating the actual probability of the hemispheric distribution of several solar activity phenomena using long-term observational records. An attempt is made to demonstrate that a long characteristic time scale, about 12-cycle length, is inferred to occur in solar activity.

Sympathetic flares are a pair of flares that occur almost simultaneously in different active regions, not by chance, but because of some physical connection. In this paper statistical evidence for the existence of sympathetic flares is presented. From GOES X-ray flare data, we have collected 48 pairs of near simultaneous flares whose positional information and Yohkoh soft X-ray telescope images are available. To select the active regions that probably have sympathetic flares, we have estimated the ratio R of actual flaring overlap time to random-coincidence overlap time for 38 active region pairs. We have then compared the waiting-time distributions for the two different groups of active region pairs (R > 1 and R < 1) with corresponding nonstationary Poisson distributions. As a result, we find a remarkable overabundance of short waiting times for the group with R > 1. This is the first time such strong statistical evidence has been found for the existence of sympathetic flares. To examine the role of interconnecting coronal loops, we have also conducted the same analysis for two subgroups of the R > 1 group: one with interconnecting X-ray loops and the other without. We do not find any statistical evidence that the subgroup with interconnecting coronal loops is more likely to produce sympathetic flares than the subgroup without. For the subgroup with loops, we find that sympathetic flares favor active region pairs with transequatorial loops.

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