Background: Tumor-like demyelinating lesion is a rare form of IP, often indistinguishable from brain tumors on CT or MR imaging. Case presentation: We report here a case of pathologically confirmed tumor-like demyelinating lesions. The clinical manifestations, image feature and pathology of this case are also discussed together with a review of the relevant literature. Conclusion: The correct diagnosis of tumor-like demyelinating lesion mainly depends on the postsurgical histopathologic examinations. We suggest complete resection of the intracranial lesion and involved dura, followed by administration of short term oral prednisolone therapy will be good for preventing recurrence.
Abstract. Multiple myeloma (MM) is a clonal B-cell malignancy charactered by the aberrant proliferation of malignant plasma cells in the bone marrow. MM is still an incurable malignancy. In this regard, novel treatments are urgently required. MUC1 (mucin 1), a type І transmembrane protein, is overexpressed and aberrantly glycosylated in many carcinomas particularly in MM resulting in an antigenically distinct molecule and may be a potential target for specific immunotherapy. In this study, we first designed a unique DNA vaccine, termed MUC1-2-VNTR (various number tandem repeats) to investigate whether the vaccine could specifically suppress tumor growth in a murine multiple myloma model. Our results showed that the constructed DNA vaccine pcDNA3.1-VNTR elicited both humoral and cellular tumor-specific immune responses in the MM mouse model leading to delay in tumor growth and prolonged survival of the mice. Consequently, our study indicates that this DNA vaccine shows promise to be used as a novel strategy for the treatment of MM.
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