Highlights d EGFR + cells sharply increase at the start of human gliogenesis d EGFR + cells contain a high proportion of progenitor cells from different lineages d EGFR + SPARCL1 + OLIG2 + cells are more like astrocytes at the transcriptional level d EGFR + astrocyte progenitor cells are mainly distributed in the OSVZ
Heterologous expression in Streptomyces coelicolor and in vitro enzyme characterization proved that two P450 enzymes, AspB and NasB, from Streptomyces sp. NRRL S-1868 catalyze two new dimerization patterns of tryptophancontaining cyclodipeptides. Structure elucidation of the metabolites revealed an N1−C7′ dimer of two cWP molecules as the predominant product of AspB and C3−C7′ connected cWP with cWA as that of NasB.
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