QALY. In univariate analysis, all variables showed significant association with ICER. However, in multivariate regression analysis, three variables; absence of alternative, disease severity and cancer, rare diseases significantly increased ICER(p< 0.05). The most influencing factor raising ICER was catastrophic disease, followed by disease severity, no alternative, and limited alternatives. The degree of impact were in 17, 14, 12, 8 millions KRW per QALY. ConClusions: This study confirmed that most of the factors were considered as modifiers of ICER on PBC's deliberation in positively recommended cases. The coefficient estimates of variables probably give an impression to any stakeholders seeking reasonable approximate ICER threshold for pharmaceuticals.
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