During the last 4 years, we had the opportunity to examine 11 patients of IgA nephropathy in childhood, in whom stainning of IgA and Cs in mesangium area was a common finding by immunofluorescent study. Urinary analysis indicated persistent microscopic hematuria and proteinuria in all cases. 8 cases among them showed macroscopic hematuria attack during the observation period. The levels of proteinuria were usually above 1 g/day. 4 cases had massive proteinuria, hypoalubminemia and hyperlipidemia, indicating nephrotic syndrome.By the light microscopic observation, the glomerular lesions of the disease with nephrotic syndrome were (1) increasing of mesangium cells and mesangium matrix, (2) creascent formation, (3) marked mononuclear cells infiltration and (4) fibrosis of interstitial area.The electron microscopic findings of them were not only showing deposits in mesangium area, but also intramembranous and subendotherial deposits. These findings suggest that there is positive correlation between the degree of proteinuria and alteration of glomerular lesion.In 3 cases of nephrotic syndrome, steroid and/or immunosuppresant therapy were employed, but no significant effect was obtained. Acta Paed. Jap, (Japanese Ed.) 83: 365-373, 1979.
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